Expanding DdCBE-mediated targeting scope to aC motif preference in rat

An animal model harboring pathogenic mitochondrial DNA (mtDNA) mutations is important to understand the biological links between mtDNA variation and mitochondrial diseases. DdCBE, a DddA-derived cytosine base editor, has been utilized in zebrafish, mice, and rats for tC sequence-context targeting an...

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Detalles Bibliográficos
Autores principales: Qi, Xiaolong, Tan, Lei, Zhang, Xu, Jin, Jiachuan, Kong, Weining, Chen, Wei, Wang, Jianying, Dong, Wei, Gao, Lijuan, Luo, Lijun, Lu, Dan, Gong, Jianan, Guan, Feifei, Shu, Wenjie, Huang, Xingxu, Zhang, Lianfeng, Wang, Shengqi, Shen, Bin, Ma, Yuanwu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10023868/
https://www.ncbi.nlm.nih.gov/pubmed/36942261
http://dx.doi.org/10.1016/j.omtn.2023.02.028

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