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Human cytochrome P450 17A1 structures with metabolites of prostate cancer drug abiraterone reveal substrate-binding plasticity and a second binding site

Abiraterone acetate is a first-line therapy for castration-resistant prostate cancer. This prodrug is deacetylated in vivo to abiraterone, which is a potent and specific inhibitor of cytochrome P450 17A1 (CYP17A1). CYP17A1 performs two sequential steps that are required for the biosynthesis of andro...

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Detalles Bibliográficos
Autores principales:	Petrunak, Elyse M., Bart, Aaron G., Peng, Hwei-Ming, Auchus, Richard J., Scott, Emily E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10023946/ https://www.ncbi.nlm.nih.gov/pubmed/36773804 http://dx.doi.org/10.1016/j.jbc.2023.102999

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