β-cell–selective inhibition of DNA damage response signaling by nitric oxide is associated with an attenuation in glucose uptake

Nitric oxide (NO) plays a dual role in regulating DNA damage response (DDR) signaling in pancreatic β-cells. As a genotoxic agent, NO activates two types of DDR signaling; however, when produced at micromolar levels by the inducible isoform of NO synthase, NO inhibits DDR signaling and DDR-induced a...

Descripción completa

Detalles Bibliográficos
Autores principales: Yeo, Chay Teng, Kropp, Erin M., Hansen, Polly A., Pereckas, Michael, Oleson, Bryndon J., Naatz, Aaron, Stancill, Jennifer S., Ross, Kyle A., Gundry, Rebekah L., Corbett, John A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10023961/
https://www.ncbi.nlm.nih.gov/pubmed/36773802
http://dx.doi.org/10.1016/j.jbc.2023.102994

Ejemplares similares

Ejemplares similares