The small molecule inhibitor NAV-2729 has a complex target profile including multiple ADP-ribosylation factor regulatory proteins

The ADP-ribosylation factor (Arf) GTPases and their regulatory proteins are implicated in cancer progression. NAV-2729 was previously identified as a specific inhibitor of Arf6 that reduced progression of uveal melanoma in an orthotopic xenograft. Here, our goal was to assess the inhibitory effects...

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Detalles Bibliográficos
Autores principales: Rosenberg, Eric M., Jian, Xiaoying, Soubias, Olivier, Yoon, Hye-Young, Yadav, Mukesh P., Hammoudeh, Sarah, Pallikkuth, Sandeep, Akpan, Itoro, Chen, Pei-Wen, Maity, Tapan K., Jenkins, Lisa M., Yohe, Marielle E., Byrd, R. Andrew, Randazzo, Paul A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10023970/
https://www.ncbi.nlm.nih.gov/pubmed/36758799
http://dx.doi.org/10.1016/j.jbc.2023.102992

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