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The complex genetic architecture of Alzheimer's disease: novel insights and future directions

BACKGROUND: Alzheimer's disease (AD) is a complex multifactorial neurodegenerative disorder and the most common form of dementia. AD is highly heritable, with heritability estimates of ∼70% from twin studies. Progressively larger genome-wide association studies (GWAS) have continued to expand o...

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Detalles Bibliográficos
Autores principales: Andrews, Shea J., Renton, Alan E., Fulton-Howard, Brian, Podlesny-Drabiniok, Anna, Marcora, Edoardo, Goate, Alison M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10024184/
https://www.ncbi.nlm.nih.gov/pubmed/36907103
http://dx.doi.org/10.1016/j.ebiom.2023.104511