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The Effects of Resveratrol on Silica-Induced Lung Oxidative Stress and Inflammation in Rat
BACKGROUND: Chronic exposure to silica is related with the provocation of an inflammatory response and oxidative stress mechanism. Vitamin D has multiple benefits in biological activities particularly respiratory system disease. METHOD: In this research, 20 male Wistar rats were randomly allocated i...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Occupational Safety and Health Research Institute
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10024237/ https://www.ncbi.nlm.nih.gov/pubmed/36941929 http://dx.doi.org/10.1016/j.shaw.2023.02.001 |
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author | Esfahani, Maryam Rahbar, Amir Hossein Asl, Sara Soleimani Bashirian, Saed Mir Moeini, Effat Sadat Mehri, Fereshteh |
author_facet | Esfahani, Maryam Rahbar, Amir Hossein Asl, Sara Soleimani Bashirian, Saed Mir Moeini, Effat Sadat Mehri, Fereshteh |
author_sort | Esfahani, Maryam |
collection | PubMed |
description | BACKGROUND: Chronic exposure to silica is related with the provocation of an inflammatory response and oxidative stress mechanism. Vitamin D has multiple benefits in biological activities particularly respiratory system disease. METHOD: In this research, 20 male Wistar rats were randomly allocated into four groups (5 rats /group) as follow: Group1 received saline as (negative control) group. The group 2 received a single IT instillation of silica (positive control) group; the group 3 was co-administrated with single IT silica and Vitamin D (20 mg/kg/day) daily for a period of 90 days. The rats of group 4 received Vitamin D daily for a period of 90 days. RESULTS: Silica significantly increased serum and lung total Oxidant Status (TOS). Meanwhile, silica reduced serum and lung total antioxidant capacity (TAC), GSH and tumor necrosis factor-α (TNF-a). Vitamin D treatment meaningfully reversed oxidative stress, antioxidants status and inflammatory response. Also, Vitamin D improved histopathological changes caused by silica. CONCLUSION: These findings indicate that Vitamin D exerts protective effects against silica-induced lung injury. It seems that Vitamin D has potential use as a therapeutic object for silica induced lung injure. |
format | Online Article Text |
id | pubmed-10024237 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Occupational Safety and Health Research Institute |
record_format | MEDLINE/PubMed |
spelling | pubmed-100242372023-03-19 The Effects of Resveratrol on Silica-Induced Lung Oxidative Stress and Inflammation in Rat Esfahani, Maryam Rahbar, Amir Hossein Asl, Sara Soleimani Bashirian, Saed Mir Moeini, Effat Sadat Mehri, Fereshteh Saf Health Work Original Article BACKGROUND: Chronic exposure to silica is related with the provocation of an inflammatory response and oxidative stress mechanism. Vitamin D has multiple benefits in biological activities particularly respiratory system disease. METHOD: In this research, 20 male Wistar rats were randomly allocated into four groups (5 rats /group) as follow: Group1 received saline as (negative control) group. The group 2 received a single IT instillation of silica (positive control) group; the group 3 was co-administrated with single IT silica and Vitamin D (20 mg/kg/day) daily for a period of 90 days. The rats of group 4 received Vitamin D daily for a period of 90 days. RESULTS: Silica significantly increased serum and lung total Oxidant Status (TOS). Meanwhile, silica reduced serum and lung total antioxidant capacity (TAC), GSH and tumor necrosis factor-α (TNF-a). Vitamin D treatment meaningfully reversed oxidative stress, antioxidants status and inflammatory response. Also, Vitamin D improved histopathological changes caused by silica. CONCLUSION: These findings indicate that Vitamin D exerts protective effects against silica-induced lung injury. It seems that Vitamin D has potential use as a therapeutic object for silica induced lung injure. Occupational Safety and Health Research Institute 2023-03 2023-02-10 /pmc/articles/PMC10024237/ /pubmed/36941929 http://dx.doi.org/10.1016/j.shaw.2023.02.001 Text en © 2023 Occupational Safety and Health Research Institute https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Original Article Esfahani, Maryam Rahbar, Amir Hossein Asl, Sara Soleimani Bashirian, Saed Mir Moeini, Effat Sadat Mehri, Fereshteh The Effects of Resveratrol on Silica-Induced Lung Oxidative Stress and Inflammation in Rat |
title | The Effects of Resveratrol on Silica-Induced Lung Oxidative Stress and Inflammation in Rat |
title_full | The Effects of Resveratrol on Silica-Induced Lung Oxidative Stress and Inflammation in Rat |
title_fullStr | The Effects of Resveratrol on Silica-Induced Lung Oxidative Stress and Inflammation in Rat |
title_full_unstemmed | The Effects of Resveratrol on Silica-Induced Lung Oxidative Stress and Inflammation in Rat |
title_short | The Effects of Resveratrol on Silica-Induced Lung Oxidative Stress and Inflammation in Rat |
title_sort | effects of resveratrol on silica-induced lung oxidative stress and inflammation in rat |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10024237/ https://www.ncbi.nlm.nih.gov/pubmed/36941929 http://dx.doi.org/10.1016/j.shaw.2023.02.001 |
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