Prostaglandin E(2) Production by Brain Endothelial Cells and the Generation of Fever

We recently demonstrated that prostaglandin production in brain endothelial cells is both necessary and sufficient for the generation of fever during systemic immune challenge. I here discuss this finding in light of the previous literature and point to some unresolved issues.

Detalles Bibliográficos
Autor principal: Blomqvist, Anders
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Mary Ann Liebert, Inc., publishers 2023
Materias:
DNACB Bit
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10024267/
https://www.ncbi.nlm.nih.gov/pubmed/36720071
http://dx.doi.org/10.1089/dna.2022.0662
Descripción
Sumario:We recently demonstrated that prostaglandin production in brain endothelial cells is both necessary and sufficient for the generation of fever during systemic immune challenge. I here discuss this finding in light of the previous literature and point to some unresolved issues.

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