Simultaneous Determination of Multicomponent Dosage Forms Using Benchtop NMR Spectroscopy: Application to Phenytoin-Phenobarbital Combination

The use of nuclear magnetic resonance (NMR) spectroscopy as a tool for determining pharmaceutical molecules in bulk drugs and their dosage forms is growing. New advancements in benchtop NMR spectrometers with cryogen-free magnets have made this technique more appealing and accessible. Herein, we dev...

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Autores principales: Nowroozi, Amin, Shahlaei, Mohsen, Kobarfard, Farzad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Brieflands 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10024314/
https://www.ncbi.nlm.nih.gov/pubmed/36942065
http://dx.doi.org/10.5812/ijpr-127040
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author Nowroozi, Amin
Shahlaei, Mohsen
Kobarfard, Farzad
author_facet Nowroozi, Amin
Shahlaei, Mohsen
Kobarfard, Farzad
author_sort Nowroozi, Amin
collection PubMed
description The use of nuclear magnetic resonance (NMR) spectroscopy as a tool for determining pharmaceutical molecules in bulk drugs and their dosage forms is growing. New advancements in benchtop NMR spectrometers with cryogen-free magnets have made this technique more appealing and accessible. Herein, we developed a method using a benchtop NMR spectrometer to quantify phenytoin (PhT) and phenobarbital (PhB) in bulk and combined dosage forms. The results were compared to those obtained by high performance liquid chromatography (HPLC) as a well-characterized procedure. This method is simple, low cost, relatively fast, and non-inferior to HPLC in terms of figures of merit.
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spelling pubmed-100243142023-03-19 Simultaneous Determination of Multicomponent Dosage Forms Using Benchtop NMR Spectroscopy: Application to Phenytoin-Phenobarbital Combination Nowroozi, Amin Shahlaei, Mohsen Kobarfard, Farzad Iran J Pharm Res Research Article The use of nuclear magnetic resonance (NMR) spectroscopy as a tool for determining pharmaceutical molecules in bulk drugs and their dosage forms is growing. New advancements in benchtop NMR spectrometers with cryogen-free magnets have made this technique more appealing and accessible. Herein, we developed a method using a benchtop NMR spectrometer to quantify phenytoin (PhT) and phenobarbital (PhB) in bulk and combined dosage forms. The results were compared to those obtained by high performance liquid chromatography (HPLC) as a well-characterized procedure. This method is simple, low cost, relatively fast, and non-inferior to HPLC in terms of figures of merit. Brieflands 2022-08-13 /pmc/articles/PMC10024314/ /pubmed/36942065 http://dx.doi.org/10.5812/ijpr-127040 Text en Copyright © 2022, Author(s) https://creativecommons.org/licenses/by-nc/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
spellingShingle Research Article
Nowroozi, Amin
Shahlaei, Mohsen
Kobarfard, Farzad
Simultaneous Determination of Multicomponent Dosage Forms Using Benchtop NMR Spectroscopy: Application to Phenytoin-Phenobarbital Combination
title Simultaneous Determination of Multicomponent Dosage Forms Using Benchtop NMR Spectroscopy: Application to Phenytoin-Phenobarbital Combination
title_full Simultaneous Determination of Multicomponent Dosage Forms Using Benchtop NMR Spectroscopy: Application to Phenytoin-Phenobarbital Combination
title_fullStr Simultaneous Determination of Multicomponent Dosage Forms Using Benchtop NMR Spectroscopy: Application to Phenytoin-Phenobarbital Combination
title_full_unstemmed Simultaneous Determination of Multicomponent Dosage Forms Using Benchtop NMR Spectroscopy: Application to Phenytoin-Phenobarbital Combination
title_short Simultaneous Determination of Multicomponent Dosage Forms Using Benchtop NMR Spectroscopy: Application to Phenytoin-Phenobarbital Combination
title_sort simultaneous determination of multicomponent dosage forms using benchtop nmr spectroscopy: application to phenytoin-phenobarbital combination
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10024314/
https://www.ncbi.nlm.nih.gov/pubmed/36942065
http://dx.doi.org/10.5812/ijpr-127040
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AT kobarfardfarzad simultaneousdeterminationofmulticomponentdosageformsusingbenchtopnmrspectroscopyapplicationtophenytoinphenobarbitalcombination

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