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Effects of Vincamine on Testicular Dysfunction in Alloxan-induced Diabetic Male Rats

BACKGROUND: Diabetes mellitus (DM) is frequently linked with problems of several organ systems, including retinopathy, neuropathy, and nephropathy. Additionally, patients have changes in sexual functioning, such as decreased libido and fertility. Vincamine, a monoterpenoid indole alkaloid, has hypog...

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Autores principales: Parlar Köprülü, Rabia Edibe, Okur, Mehmet Evren, Kolbaşi, Bircan, Keskin, İlknur, Ozbek, Hanefi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Brieflands 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10024332/
https://www.ncbi.nlm.nih.gov/pubmed/36942057
http://dx.doi.org/10.5812/ijpr-132265
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author Parlar Köprülü, Rabia Edibe
Okur, Mehmet Evren
Kolbaşi, Bircan
Keskin, İlknur
Ozbek, Hanefi
author_facet Parlar Köprülü, Rabia Edibe
Okur, Mehmet Evren
Kolbaşi, Bircan
Keskin, İlknur
Ozbek, Hanefi
author_sort Parlar Köprülü, Rabia Edibe
collection PubMed
description BACKGROUND: Diabetes mellitus (DM) is frequently linked with problems of several organ systems, including retinopathy, neuropathy, and nephropathy. Additionally, patients have changes in sexual functioning, such as decreased libido and fertility. Vincamine, a monoterpenoid indole alkaloid, has hypoglycemic and antioxidant effects. OBJECTIVES: This research assessed the impact of vincamine on testicular dysfunction in alloxan-induced male rats by measuring fasting blood glucose, oxidative stress, seminal analysis, and histological examination of the testis. METHODS: Wister-albino male rats were randomized into the following groups at random: Untreated-healthy, untreated-DM, vincamine-treated (20 mg/kg) DM, vincamine-treated (40 mg/kg) DM, and clomiphene-treated DM (5 mg/kg). On day 14, rats were sacrificed, and semen/blood samples were collected. Sperm count, motility, and morphological abnormalities were noted by microscopic examination. The testis was examined histopathologically and assessed using Johnsen’s score. RESULTS: Compared with the untreated diabetic group, a dosage of 40 mg/kg vincamine generate a significant reduction in fasting blood sugar (FBG). Compared with the untreated diabetic group, the vincamine-treated rats produced greater plasma testosterone levels and Johnsen scores. In the vincamine 20 mg/kg group, sperm concentration was higher than in the vincamine 40 mg/kg group. CONCLUSIONS: It is possible that vincamine has a potential preventive effect against diabetes-related reproductive problems attributable to its antioxidant activity and capacity to restore testicular steroidogenesis.
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spelling pubmed-100243322023-03-19 Effects of Vincamine on Testicular Dysfunction in Alloxan-induced Diabetic Male Rats Parlar Köprülü, Rabia Edibe Okur, Mehmet Evren Kolbaşi, Bircan Keskin, İlknur Ozbek, Hanefi Iran J Pharm Res Research Article BACKGROUND: Diabetes mellitus (DM) is frequently linked with problems of several organ systems, including retinopathy, neuropathy, and nephropathy. Additionally, patients have changes in sexual functioning, such as decreased libido and fertility. Vincamine, a monoterpenoid indole alkaloid, has hypoglycemic and antioxidant effects. OBJECTIVES: This research assessed the impact of vincamine on testicular dysfunction in alloxan-induced male rats by measuring fasting blood glucose, oxidative stress, seminal analysis, and histological examination of the testis. METHODS: Wister-albino male rats were randomized into the following groups at random: Untreated-healthy, untreated-DM, vincamine-treated (20 mg/kg) DM, vincamine-treated (40 mg/kg) DM, and clomiphene-treated DM (5 mg/kg). On day 14, rats were sacrificed, and semen/blood samples were collected. Sperm count, motility, and morphological abnormalities were noted by microscopic examination. The testis was examined histopathologically and assessed using Johnsen’s score. RESULTS: Compared with the untreated diabetic group, a dosage of 40 mg/kg vincamine generate a significant reduction in fasting blood sugar (FBG). Compared with the untreated diabetic group, the vincamine-treated rats produced greater plasma testosterone levels and Johnsen scores. In the vincamine 20 mg/kg group, sperm concentration was higher than in the vincamine 40 mg/kg group. CONCLUSIONS: It is possible that vincamine has a potential preventive effect against diabetes-related reproductive problems attributable to its antioxidant activity and capacity to restore testicular steroidogenesis. Brieflands 2023-01-20 /pmc/articles/PMC10024332/ /pubmed/36942057 http://dx.doi.org/10.5812/ijpr-132265 Text en Copyright © 2022, Author(s) https://creativecommons.org/licenses/by-nc/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
spellingShingle Research Article
Parlar Köprülü, Rabia Edibe
Okur, Mehmet Evren
Kolbaşi, Bircan
Keskin, İlknur
Ozbek, Hanefi
Effects of Vincamine on Testicular Dysfunction in Alloxan-induced Diabetic Male Rats
title Effects of Vincamine on Testicular Dysfunction in Alloxan-induced Diabetic Male Rats
title_full Effects of Vincamine on Testicular Dysfunction in Alloxan-induced Diabetic Male Rats
title_fullStr Effects of Vincamine on Testicular Dysfunction in Alloxan-induced Diabetic Male Rats
title_full_unstemmed Effects of Vincamine on Testicular Dysfunction in Alloxan-induced Diabetic Male Rats
title_short Effects of Vincamine on Testicular Dysfunction in Alloxan-induced Diabetic Male Rats
title_sort effects of vincamine on testicular dysfunction in alloxan-induced diabetic male rats
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10024332/
https://www.ncbi.nlm.nih.gov/pubmed/36942057
http://dx.doi.org/10.5812/ijpr-132265
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