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Subthalamic Nucleus (STN)-Deep Brain Stimulation Reduces the Power of Mu and Beta Rhythms and Enhances Synchrony at the Motor Cortices in Parkinson's Disease: A Report of Two Cases
The motor circuit in Parkinson’s disease (PD) involves the basal ganglia, thalamus, motor cortex, and cerebellum. Hence, subthalamic nucleus (STN) or globus pallidus internus deep brain stimulation is commonly used in treating refractory Parkinson’s patients. During the procedure, the local field po...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Cureus
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10024512/ https://www.ncbi.nlm.nih.gov/pubmed/36942168 http://dx.doi.org/10.7759/cureus.35057 |
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author | Zakaria, Zaitun Idris, Zamzuri Abdul Halim, Sanihah Ghani, Abdul Rahman Izaini Abdullah, Jafri M |
author_facet | Zakaria, Zaitun Idris, Zamzuri Abdul Halim, Sanihah Ghani, Abdul Rahman Izaini Abdullah, Jafri M |
author_sort | Zakaria, Zaitun |
collection | PubMed |
description | The motor circuit in Parkinson’s disease (PD) involves the basal ganglia, thalamus, motor cortex, and cerebellum. Hence, subthalamic nucleus (STN) or globus pallidus internus deep brain stimulation is commonly used in treating refractory Parkinson’s patients. During the procedure, the local field potential (LPF) is commonly made along the trajectory of the STN. Two cases were assessed, where an electroencephalographic recording at the sensorimotor cortices was also performed with and without stimulation at the optimal STN electrode site. The ‘on’ stimulation state associated with clinical improvement correlated with a marked reduction in the late theta (7.5 Hz), alpha (10.5 Hz) (Mu wave), and beta (20 Hz) wave power. Besides, more synchronized and coherent brainwaves were noted when the stimulation was ‘on’. |
format | Online Article Text |
id | pubmed-10024512 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Cureus |
record_format | MEDLINE/PubMed |
spelling | pubmed-100245122023-03-19 Subthalamic Nucleus (STN)-Deep Brain Stimulation Reduces the Power of Mu and Beta Rhythms and Enhances Synchrony at the Motor Cortices in Parkinson's Disease: A Report of Two Cases Zakaria, Zaitun Idris, Zamzuri Abdul Halim, Sanihah Ghani, Abdul Rahman Izaini Abdullah, Jafri M Cureus Medical Simulation The motor circuit in Parkinson’s disease (PD) involves the basal ganglia, thalamus, motor cortex, and cerebellum. Hence, subthalamic nucleus (STN) or globus pallidus internus deep brain stimulation is commonly used in treating refractory Parkinson’s patients. During the procedure, the local field potential (LPF) is commonly made along the trajectory of the STN. Two cases were assessed, where an electroencephalographic recording at the sensorimotor cortices was also performed with and without stimulation at the optimal STN electrode site. The ‘on’ stimulation state associated with clinical improvement correlated with a marked reduction in the late theta (7.5 Hz), alpha (10.5 Hz) (Mu wave), and beta (20 Hz) wave power. Besides, more synchronized and coherent brainwaves were noted when the stimulation was ‘on’. Cureus 2023-02-16 /pmc/articles/PMC10024512/ /pubmed/36942168 http://dx.doi.org/10.7759/cureus.35057 Text en Copyright © 2023, Zakaria et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Medical Simulation Zakaria, Zaitun Idris, Zamzuri Abdul Halim, Sanihah Ghani, Abdul Rahman Izaini Abdullah, Jafri M Subthalamic Nucleus (STN)-Deep Brain Stimulation Reduces the Power of Mu and Beta Rhythms and Enhances Synchrony at the Motor Cortices in Parkinson's Disease: A Report of Two Cases |
title | Subthalamic Nucleus (STN)-Deep Brain Stimulation Reduces the Power of Mu and Beta Rhythms and Enhances Synchrony at the Motor Cortices in Parkinson's Disease: A Report of Two Cases |
title_full | Subthalamic Nucleus (STN)-Deep Brain Stimulation Reduces the Power of Mu and Beta Rhythms and Enhances Synchrony at the Motor Cortices in Parkinson's Disease: A Report of Two Cases |
title_fullStr | Subthalamic Nucleus (STN)-Deep Brain Stimulation Reduces the Power of Mu and Beta Rhythms and Enhances Synchrony at the Motor Cortices in Parkinson's Disease: A Report of Two Cases |
title_full_unstemmed | Subthalamic Nucleus (STN)-Deep Brain Stimulation Reduces the Power of Mu and Beta Rhythms and Enhances Synchrony at the Motor Cortices in Parkinson's Disease: A Report of Two Cases |
title_short | Subthalamic Nucleus (STN)-Deep Brain Stimulation Reduces the Power of Mu and Beta Rhythms and Enhances Synchrony at the Motor Cortices in Parkinson's Disease: A Report of Two Cases |
title_sort | subthalamic nucleus (stn)-deep brain stimulation reduces the power of mu and beta rhythms and enhances synchrony at the motor cortices in parkinson's disease: a report of two cases |
topic | Medical Simulation |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10024512/ https://www.ncbi.nlm.nih.gov/pubmed/36942168 http://dx.doi.org/10.7759/cureus.35057 |
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