Inhibition of PD-1 Alters the SHP1/2-PI3K/Akt Axis to Decrease M1 Polarization of Alveolar Macrophages in Lung Ischemia–Reperfusion Injury

Polarization of alveolar macrophages (AMs) into the M1 phenotype contributes to inflammatory responses and tissue damage that occur during lung ischemia–reperfusion injury (LIRI). Programmed cell death factor-1 (PD-1) regulates polarization of macrophages, but its role in LIRI is unknown. We examine...

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Detalles Bibliográficos
Autores principales: He, Xiaojing, Xiao, Jingyuan, Li, Zhao, Ye, Mengling, Lin, Jinyuan, Liu, Zhen, Liang, Yubing, Dai, Huijun, Jing, Ren, Lin, Fei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10024672/
https://www.ncbi.nlm.nih.gov/pubmed/36357527
http://dx.doi.org/10.1007/s10753-022-01762-6

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