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The structural flexibility of MAD1 facilitates the assembly of the Mitotic Checkpoint Complex

The spindle assembly checkpoint (SAC) safeguards the genome during cell division by generating an effector molecule known as the Mitotic Checkpoint Complex (MCC). The MCC comprises two subcomplexes: BUBR1:BUB3 and CDC20:MAD2, and the formation of CDC20:MAD2 is the rate-limiting step during MCC assem...

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Detalles Bibliográficos
Autores principales:	Chen, Chu, Piano, Valentina, Alex, Amal, Han, Simon J. Y., Huis in ’t Veld, Pim J., Roy, Babhrubahan, Fergle, Daniel, Musacchio, Andrea, Joglekar, Ajit P.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10024682/ https://www.ncbi.nlm.nih.gov/pubmed/36934097 http://dx.doi.org/10.1038/s41467-023-37235-z

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