Enhanced excitability but mature action potential waveforms at mossy fiber terminals of young, adult-born hippocampal neurons in mice

Adult-born granule neurons pass through immature critical periods where they display enhanced somatic excitability and afferent plasticity, which is believed to endow them with unique roles in hippocampal learning and memory. Using patch clamp recordings in mouse hippocampal slices, here we show tha...

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Autores principales: Vyleta, Nicholas P., Snyder, Jason S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10024705/
https://www.ncbi.nlm.nih.gov/pubmed/36934174
http://dx.doi.org/10.1038/s42003-023-04678-5
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author Vyleta, Nicholas P.
Snyder, Jason S.
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Snyder, Jason S.
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description Adult-born granule neurons pass through immature critical periods where they display enhanced somatic excitability and afferent plasticity, which is believed to endow them with unique roles in hippocampal learning and memory. Using patch clamp recordings in mouse hippocampal slices, here we show that young neuron hyper-excitability is also observed at presynaptic mossy fiber terminals onto CA3 pyramidal neurons. However, action potential waveforms mature faster in the bouton than in the soma, suggesting rapid efferent functionality during immature stages.
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spelling pubmed-100247052023-03-20 Enhanced excitability but mature action potential waveforms at mossy fiber terminals of young, adult-born hippocampal neurons in mice Vyleta, Nicholas P. Snyder, Jason S. Commun Biol Article Adult-born granule neurons pass through immature critical periods where they display enhanced somatic excitability and afferent plasticity, which is believed to endow them with unique roles in hippocampal learning and memory. Using patch clamp recordings in mouse hippocampal slices, here we show that young neuron hyper-excitability is also observed at presynaptic mossy fiber terminals onto CA3 pyramidal neurons. However, action potential waveforms mature faster in the bouton than in the soma, suggesting rapid efferent functionality during immature stages. Nature Publishing Group UK 2023-03-18 /pmc/articles/PMC10024705/ /pubmed/36934174 http://dx.doi.org/10.1038/s42003-023-04678-5 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Vyleta, Nicholas P.
Snyder, Jason S.
Enhanced excitability but mature action potential waveforms at mossy fiber terminals of young, adult-born hippocampal neurons in mice
title Enhanced excitability but mature action potential waveforms at mossy fiber terminals of young, adult-born hippocampal neurons in mice
title_full Enhanced excitability but mature action potential waveforms at mossy fiber terminals of young, adult-born hippocampal neurons in mice
title_fullStr Enhanced excitability but mature action potential waveforms at mossy fiber terminals of young, adult-born hippocampal neurons in mice
title_full_unstemmed Enhanced excitability but mature action potential waveforms at mossy fiber terminals of young, adult-born hippocampal neurons in mice
title_short Enhanced excitability but mature action potential waveforms at mossy fiber terminals of young, adult-born hippocampal neurons in mice
title_sort enhanced excitability but mature action potential waveforms at mossy fiber terminals of young, adult-born hippocampal neurons in mice
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10024705/
https://www.ncbi.nlm.nih.gov/pubmed/36934174
http://dx.doi.org/10.1038/s42003-023-04678-5
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