Synthetic lethality of drug-induced polyploidy and BCL-2 inhibition in lymphoma

Spontaneous whole genome duplication and the adaptive mutations that disrupt genome integrity checkpoints are infrequent events in B cell lymphomas. This suggests that lymphomas might be vulnerable to therapeutics that acutely trigger genomic instability and polyploidy. Here, we report a therapeutic...

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Detalles Bibliográficos
Autores principales: Portelinha, Ana, da Silva Ferreira, Mariana, Erazo, Tatiana, Jiang, Man, Asgari, Zahra, de Stanchina, Elisa, Younes, Anas, Wendel, Hans-Guido
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10024740/
https://www.ncbi.nlm.nih.gov/pubmed/36934096
http://dx.doi.org/10.1038/s41467-023-37216-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10024740/
https://www.ncbi.nlm.nih.gov/pubmed/36934096
http://dx.doi.org/10.1038/s41467-023-37216-2

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