On frailty and accelerated aging during SARS-Cov-2: senescence

The COVID-19 pandemic is a burden for the worldwide healthcare systems. Whereas a clear age-dependent mortality can be observed, especially multimorbid and frail persons are at an increased risk. As bio-functional rather than calendrical age is in the meanwhile known to play a crucial role for COVID...

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Autores principales: Müller-Werdan, Ursula, Polidori, M. Cristina, Simm, Andreas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10025062/
https://www.ncbi.nlm.nih.gov/pubmed/36935472
http://dx.doi.org/10.1007/s40520-023-02364-4
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author Müller-Werdan, Ursula
Polidori, M. Cristina
Simm, Andreas
author_facet Müller-Werdan, Ursula
Polidori, M. Cristina
Simm, Andreas
author_sort Müller-Werdan, Ursula
collection PubMed
description The COVID-19 pandemic is a burden for the worldwide healthcare systems. Whereas a clear age-dependent mortality can be observed, especially multimorbid and frail persons are at an increased risk. As bio-functional rather than calendrical age is in the meanwhile known to play a crucial role for COVID-19-related outcomes, aging-associated risk factors, overall prognosis and physiological age-related changes should be systematically considered for clinical decision-making. In this overview, we focus on cellular senescence as a major factor of biological aging, associated with organ dysfunction and increased inflammation (inflammaging).
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spelling pubmed-100250622023-03-21 On frailty and accelerated aging during SARS-Cov-2: senescence Müller-Werdan, Ursula Polidori, M. Cristina Simm, Andreas Aging Clin Exp Res Original Article The COVID-19 pandemic is a burden for the worldwide healthcare systems. Whereas a clear age-dependent mortality can be observed, especially multimorbid and frail persons are at an increased risk. As bio-functional rather than calendrical age is in the meanwhile known to play a crucial role for COVID-19-related outcomes, aging-associated risk factors, overall prognosis and physiological age-related changes should be systematically considered for clinical decision-making. In this overview, we focus on cellular senescence as a major factor of biological aging, associated with organ dysfunction and increased inflammation (inflammaging). Springer International Publishing 2023-03-20 2023 /pmc/articles/PMC10025062/ /pubmed/36935472 http://dx.doi.org/10.1007/s40520-023-02364-4 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Original Article
Müller-Werdan, Ursula
Polidori, M. Cristina
Simm, Andreas
On frailty and accelerated aging during SARS-Cov-2: senescence
title On frailty and accelerated aging during SARS-Cov-2: senescence
title_full On frailty and accelerated aging during SARS-Cov-2: senescence
title_fullStr On frailty and accelerated aging during SARS-Cov-2: senescence
title_full_unstemmed On frailty and accelerated aging during SARS-Cov-2: senescence
title_short On frailty and accelerated aging during SARS-Cov-2: senescence
title_sort on frailty and accelerated aging during sars-cov-2: senescence
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10025062/
https://www.ncbi.nlm.nih.gov/pubmed/36935472
http://dx.doi.org/10.1007/s40520-023-02364-4
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