Cancer vaccines based on whole-tumor lysate or neoepitopes with validated HLA binding outperform those with predicted HLA-binding affinity

Antigen selection and prioritization represent crucial determinants of vaccines’ efficacy. Here, we compare two personalized dendritic cell-based vaccination strategies using whole-tumor lysate or neoantigens. Data in mouse and in cancer patients demonstrate that peptide vaccines using neoantigens p...

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Detalles Bibliográficos
Autores principales: Fritah, Hajer, Graciotti, Michele, Lai-Lai Chiang, Cheryl, Huguenin- Bergenat, Anne-Laure, Petremand, Rémy, Ahmed, Ritaparna, Guillaume, Philippe, Schmidt, Julien, Stevenson, Brian J., Gfeller, David, Harari, Alexandre, Kandalaft, Lana E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10025090/
https://www.ncbi.nlm.nih.gov/pubmed/36950115
http://dx.doi.org/10.1016/j.isci.2023.106288

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