Activation of AMP-activated protein kinase (AMPK) through inhibiting interaction with prohibitins

5′-Adenosine monophosphate-activated protein kinase (AMPK) is a potential therapeutic target for various medical conditions. We here identify a small-molecule compound (RX-375) that activates AMPK and inhibits fatty acid synthesis in cultured human hepatocytes. RX-375 does not bind to AMPK but inter...

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Detalles Bibliográficos
Autores principales: Kanagaki, Shuhei, Tsutsui, Yusuke, Kobayashi, Naoki, Komine, Takashi, Ito, Minoru, Akasaka, Yunike, Nagasawa, Michiaki, Ide, Tomohiro, Omae, Naoki, Nakao, Kazuhisa, Rembutsu, Makoto, Iwago, Maki, Yonezawa, Aki, Hosokawa, Yusei, Hosooka, Tetsuya, Ogawa, Wataru, Murakami, Koji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10025096/
https://www.ncbi.nlm.nih.gov/pubmed/36950117
http://dx.doi.org/10.1016/j.isci.2023.106293

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