p38 MAPK and MKP-1 control the glycolytic program via the bifunctional glycolysis regulator PFKFB3 during sepsis

Hyperlactatemia often occurs in critically ill patients during severe sepsis/septic shock and is a powerful predictor of mortality. Lactate is the end product of glycolysis. While hypoxia due to inadequate oxygen delivery may result in anaerobic glycolysis, sepsis also enhances glycolysis under hype...

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Detalles Bibliográficos
Autores principales: Mager, Carli E., Mormol, Justin M., Shelton, Evan D., Murphy, Parker R., Bowman, Bridget A., Barley, Timothy J., Wang, Xiantao, Linn, Sarah C., Liu, Kevin, Nelin, Leif D., Hafner, Markus, Liu, Yusen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10025163/
https://www.ncbi.nlm.nih.gov/pubmed/36803959
http://dx.doi.org/10.1016/j.jbc.2023.103043

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