Now you see me: lights on Merkel Cell Carcinoma

Merkel Cell Carcinoma (MCC) is a rare primary cutaneous cancer with aggressive behaviour and poor prognosis. Although MCC cells express somatostatin receptors (SSTR), SSTR-targeted PET/CT is not routinely performed in clinical practice. In contrast, the use of [(18)F]FDG PET/CT is more widespread an...

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Detalles Bibliográficos
Autores principales: Pini, Cristiano, Matassa, Giovanni, Gelardi, Fabrizia, Antunovic, Lidija
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2023
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10025171/
https://www.ncbi.nlm.nih.gov/pubmed/36935458
http://dx.doi.org/10.1186/s41824-023-00164-7
Descripción
Sumario:Merkel Cell Carcinoma (MCC) is a rare primary cutaneous cancer with aggressive behaviour and poor prognosis. Although MCC cells express somatostatin receptors (SSTR), SSTR-targeted PET/CT is not routinely performed in clinical practice. In contrast, the use of [(18)F]FDG PET/CT is more widespread and its prognostic role is well established. We present the case of an MCC patient suspected recurrence who underwent restaging with both [(18)F]FDG and [(68) Ga]Ga-DOTA-TOC PET/CT. [(18)F]FDG PET/CT showed pathological uptake only in mediastinal lymph nodes, but SSTR imaging also revealed multiple liver and skeletal metastases, leading to significant disease upstaging and relevant changes in the therapeutic management.

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