Now you see me: lights on Merkel Cell Carcinoma

Merkel Cell Carcinoma (MCC) is a rare primary cutaneous cancer with aggressive behaviour and poor prognosis. Although MCC cells express somatostatin receptors (SSTR), SSTR-targeted PET/CT is not routinely performed in clinical practice. In contrast, the use of [(18)F]FDG PET/CT is more widespread an...

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Autores principales: Pini, Cristiano, Matassa, Giovanni, Gelardi, Fabrizia, Antunovic, Lidija
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2023
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10025171/
https://www.ncbi.nlm.nih.gov/pubmed/36935458
http://dx.doi.org/10.1186/s41824-023-00164-7
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author Pini, Cristiano
Matassa, Giovanni
Gelardi, Fabrizia
Antunovic, Lidija
author_facet Pini, Cristiano
Matassa, Giovanni
Gelardi, Fabrizia
Antunovic, Lidija
author_sort Pini, Cristiano
collection PubMed
description Merkel Cell Carcinoma (MCC) is a rare primary cutaneous cancer with aggressive behaviour and poor prognosis. Although MCC cells express somatostatin receptors (SSTR), SSTR-targeted PET/CT is not routinely performed in clinical practice. In contrast, the use of [(18)F]FDG PET/CT is more widespread and its prognostic role is well established. We present the case of an MCC patient suspected recurrence who underwent restaging with both [(18)F]FDG and [(68) Ga]Ga-DOTA-TOC PET/CT. [(18)F]FDG PET/CT showed pathological uptake only in mediastinal lymph nodes, but SSTR imaging also revealed multiple liver and skeletal metastases, leading to significant disease upstaging and relevant changes in the therapeutic management.
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spelling pubmed-100251712023-03-21 Now you see me: lights on Merkel Cell Carcinoma Pini, Cristiano Matassa, Giovanni Gelardi, Fabrizia Antunovic, Lidija Eur J Hybrid Imaging Case Report Merkel Cell Carcinoma (MCC) is a rare primary cutaneous cancer with aggressive behaviour and poor prognosis. Although MCC cells express somatostatin receptors (SSTR), SSTR-targeted PET/CT is not routinely performed in clinical practice. In contrast, the use of [(18)F]FDG PET/CT is more widespread and its prognostic role is well established. We present the case of an MCC patient suspected recurrence who underwent restaging with both [(18)F]FDG and [(68) Ga]Ga-DOTA-TOC PET/CT. [(18)F]FDG PET/CT showed pathological uptake only in mediastinal lymph nodes, but SSTR imaging also revealed multiple liver and skeletal metastases, leading to significant disease upstaging and relevant changes in the therapeutic management. Springer International Publishing 2023-03-20 /pmc/articles/PMC10025171/ /pubmed/36935458 http://dx.doi.org/10.1186/s41824-023-00164-7 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Case Report
Pini, Cristiano
Matassa, Giovanni
Gelardi, Fabrizia
Antunovic, Lidija
Now you see me: lights on Merkel Cell Carcinoma
title Now you see me: lights on Merkel Cell Carcinoma
title_full Now you see me: lights on Merkel Cell Carcinoma
title_fullStr Now you see me: lights on Merkel Cell Carcinoma
title_full_unstemmed Now you see me: lights on Merkel Cell Carcinoma
title_short Now you see me: lights on Merkel Cell Carcinoma
title_sort now you see me: lights on merkel cell carcinoma
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10025171/
https://www.ncbi.nlm.nih.gov/pubmed/36935458
http://dx.doi.org/10.1186/s41824-023-00164-7
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