Dominant-negative transforming growth factor-β receptor-armoured mesothelin-targeted chimeric antigen receptor T cells slow tumour growth in a mouse model of ovarian cancer

Ovarian cancer is a major cause of death among all gynaecological cancers. Although surgery, chemotherapy and targeted therapy have yielded successful outcomes, the 5-year survival rate remains < 30%. Adoptive immunotherapy, particularly chimeric antigen receptor (CAR) T-cell therapy, has demonst...

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Detalles Bibliográficos
Autores principales: Li, Ke, Xu, Jing, Wang, Jing, Lu, Chong, Dai, Yilin, Dai, Qing, Zhang, Wang, Xu, Congjian, Wu, Shu, Kang, Yu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10025183/
https://www.ncbi.nlm.nih.gov/pubmed/36166071
http://dx.doi.org/10.1007/s00262-022-03290-6

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