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Gasdermin D membrane pores orchestrate IL-1α secretion from necrotic macrophages after NFS-rich silica exposure

IL-1α is an intracellular danger signal (DAMP) released by macrophages contributing to the development of silica-induced lung inflammation. The exact molecular mechanism orchestrating IL-1α extracellular release from particle-exposed macrophages is still unclear. To delineate this process, murine J7...

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Detalles Bibliográficos
Autores principales:	Leinardi, Riccardo, Pochet, Amandine, Uwambayinema, Francine, Yakoub, Yousof, Quesniaux, Valérie, Ryffel, Bernhard, Broz, Petr, Pavan, Cristina, Huaux, François
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Berlin Heidelberg 2023
Materias:	Inorganic Compounds
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10025216/ https://www.ncbi.nlm.nih.gov/pubmed/36840754 http://dx.doi.org/10.1007/s00204-023-03463-x

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