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Impaired glymphatic drainage underlying obstructive sleep apnea is associated with cognitive dysfunction
Obstructive sleep apnea (OSA) is highly prevalent but easily undiagnosed and is an independent risk factor for cognitive impairment. However, it remains unclear how OSA is linked to cognitive impairment. In the present study, we found the correlation between morphological changes of perivascular spa...
Autores principales: | , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Berlin Heidelberg
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10025229/ https://www.ncbi.nlm.nih.gov/pubmed/36662283 http://dx.doi.org/10.1007/s00415-022-11530-z |
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author | Wang, Jiuqi Tian, Yiming Qin, Chi Meng, Lin Feng, Renyi Xu, Shuqin Zhai, Yanping Liang, Dongxiao Zhang, Rui Tian, Haiyan Liu, Han Chen, Yongkang Fu, Yu Chen, Pei Zhu, Qingyong Teng, Junfang Wang, Xuejing |
author_facet | Wang, Jiuqi Tian, Yiming Qin, Chi Meng, Lin Feng, Renyi Xu, Shuqin Zhai, Yanping Liang, Dongxiao Zhang, Rui Tian, Haiyan Liu, Han Chen, Yongkang Fu, Yu Chen, Pei Zhu, Qingyong Teng, Junfang Wang, Xuejing |
author_sort | Wang, Jiuqi |
collection | PubMed |
description | Obstructive sleep apnea (OSA) is highly prevalent but easily undiagnosed and is an independent risk factor for cognitive impairment. However, it remains unclear how OSA is linked to cognitive impairment. In the present study, we found the correlation between morphological changes of perivascular spaces (PVSs) and cognitive impairment in OSA patients. Moreover, we developed a novel set of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) methods to evaluate the fluid dynamics of glymphatic drainage system. We found that the inflow and outflow parameters of the glymphatic drainage system in patients with OSA were obviously changed, indicating impairment of glymphatic drainage due to excessive perfusion accompanied with deficient drainage in OSA patients. Moreover, parameters of the outflow were associated with the degree of cognitive impairment, as well as the hypoxia level. In addition, continuous positive airway pressure (CPAP) enhances performance of the glymphatic drainage system after 1 month treatment in OSA patients. We proposed that ventilation improvement might be a new strategy to ameliorate the impaired drainage of glymphatic drainage system due to OSA-induced chronic intermittent hypoxia, and consequently improved the cognitive decline. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s00415-022-11530-z. |
format | Online Article Text |
id | pubmed-10025229 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Springer Berlin Heidelberg |
record_format | MEDLINE/PubMed |
spelling | pubmed-100252292023-03-21 Impaired glymphatic drainage underlying obstructive sleep apnea is associated with cognitive dysfunction Wang, Jiuqi Tian, Yiming Qin, Chi Meng, Lin Feng, Renyi Xu, Shuqin Zhai, Yanping Liang, Dongxiao Zhang, Rui Tian, Haiyan Liu, Han Chen, Yongkang Fu, Yu Chen, Pei Zhu, Qingyong Teng, Junfang Wang, Xuejing J Neurol Original Communication Obstructive sleep apnea (OSA) is highly prevalent but easily undiagnosed and is an independent risk factor for cognitive impairment. However, it remains unclear how OSA is linked to cognitive impairment. In the present study, we found the correlation between morphological changes of perivascular spaces (PVSs) and cognitive impairment in OSA patients. Moreover, we developed a novel set of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) methods to evaluate the fluid dynamics of glymphatic drainage system. We found that the inflow and outflow parameters of the glymphatic drainage system in patients with OSA were obviously changed, indicating impairment of glymphatic drainage due to excessive perfusion accompanied with deficient drainage in OSA patients. Moreover, parameters of the outflow were associated with the degree of cognitive impairment, as well as the hypoxia level. In addition, continuous positive airway pressure (CPAP) enhances performance of the glymphatic drainage system after 1 month treatment in OSA patients. We proposed that ventilation improvement might be a new strategy to ameliorate the impaired drainage of glymphatic drainage system due to OSA-induced chronic intermittent hypoxia, and consequently improved the cognitive decline. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s00415-022-11530-z. Springer Berlin Heidelberg 2023-01-20 2023 /pmc/articles/PMC10025229/ /pubmed/36662283 http://dx.doi.org/10.1007/s00415-022-11530-z Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Original Communication Wang, Jiuqi Tian, Yiming Qin, Chi Meng, Lin Feng, Renyi Xu, Shuqin Zhai, Yanping Liang, Dongxiao Zhang, Rui Tian, Haiyan Liu, Han Chen, Yongkang Fu, Yu Chen, Pei Zhu, Qingyong Teng, Junfang Wang, Xuejing Impaired glymphatic drainage underlying obstructive sleep apnea is associated with cognitive dysfunction |
title | Impaired glymphatic drainage underlying obstructive sleep apnea is associated with cognitive dysfunction |
title_full | Impaired glymphatic drainage underlying obstructive sleep apnea is associated with cognitive dysfunction |
title_fullStr | Impaired glymphatic drainage underlying obstructive sleep apnea is associated with cognitive dysfunction |
title_full_unstemmed | Impaired glymphatic drainage underlying obstructive sleep apnea is associated with cognitive dysfunction |
title_short | Impaired glymphatic drainage underlying obstructive sleep apnea is associated with cognitive dysfunction |
title_sort | impaired glymphatic drainage underlying obstructive sleep apnea is associated with cognitive dysfunction |
topic | Original Communication |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10025229/ https://www.ncbi.nlm.nih.gov/pubmed/36662283 http://dx.doi.org/10.1007/s00415-022-11530-z |
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