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Associations between neuropsychiatric symptoms and incident Alzheimer’s dementia in men versus women

OBJECTIVE: To examine whether associations between individual neuropsychiatric symptoms (NPS) and incident Alzheimer’s dementia (AD) differ in men versus women. METHODS: Data were acquired from the National Alzheimer’s Coordinating Center (NACC) Uniform Data Set. Two sets of older (≥ 60 years) parti...

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Autores principales: Liampas, Ioannis, Siokas, Vasileios, Lyketsos, Constantine G., Dardiotis, Efthimios
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10025238/
https://www.ncbi.nlm.nih.gov/pubmed/36572715
http://dx.doi.org/10.1007/s00415-022-11541-w
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author Liampas, Ioannis
Siokas, Vasileios
Lyketsos, Constantine G.
Dardiotis, Efthimios
author_facet Liampas, Ioannis
Siokas, Vasileios
Lyketsos, Constantine G.
Dardiotis, Efthimios
author_sort Liampas, Ioannis
collection PubMed
description OBJECTIVE: To examine whether associations between individual neuropsychiatric symptoms (NPS) and incident Alzheimer’s dementia (AD) differ in men versus women. METHODS: Data were acquired from the National Alzheimer’s Coordinating Center (NACC) Uniform Data Set. Two sets of older (≥ 60 years) participants were formed: one of cognitively unimpaired (CU) individuals, and one of participants with mild cognitive impairment (MCI). NPS were assessed using the Neuropsychiatric Inventory Questionnaire. Cox proportional hazards models examined associations between individual NPS and AD incidence separately for each participant set. These models featured individual NPS, sex, NPS by sex interactions as well as a number of covariates. RESULTS: The analysis involved 9,854 CU individuals followed for 5.5 ± 3.8 years and 6,369 participants with MCI followed for 3.8 ± 3.0 years. NPS were comparably associated with future AD in men and women with MCI. Regarding CU participants, the following significant sex by NPS interactions were noted: female sex moderated the risk conferred by moderate/severe apathy (HR = 7.36, 3.25–16.64) by 74%, mitigated the risk conferred by moderate/severe depression (HR = 3.61, 2.08–6.28) by 52%, and augmented the risks conferred by mild depression (HR = 1.00, 0.60–1.68) and agitation (HR = 0.81, 0.40–1.64) by 83% and 243%, respectively. CONCLUSIONS: Apathy, depression and agitation were differentially associated with incident AD in CU men and women. No individual NPS was associated with different risks of future AD in men versus women with MCI. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s00415-022-11541-w.
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spelling pubmed-100252382023-03-21 Associations between neuropsychiatric symptoms and incident Alzheimer’s dementia in men versus women Liampas, Ioannis Siokas, Vasileios Lyketsos, Constantine G. Dardiotis, Efthimios J Neurol Original Communication OBJECTIVE: To examine whether associations between individual neuropsychiatric symptoms (NPS) and incident Alzheimer’s dementia (AD) differ in men versus women. METHODS: Data were acquired from the National Alzheimer’s Coordinating Center (NACC) Uniform Data Set. Two sets of older (≥ 60 years) participants were formed: one of cognitively unimpaired (CU) individuals, and one of participants with mild cognitive impairment (MCI). NPS were assessed using the Neuropsychiatric Inventory Questionnaire. Cox proportional hazards models examined associations between individual NPS and AD incidence separately for each participant set. These models featured individual NPS, sex, NPS by sex interactions as well as a number of covariates. RESULTS: The analysis involved 9,854 CU individuals followed for 5.5 ± 3.8 years and 6,369 participants with MCI followed for 3.8 ± 3.0 years. NPS were comparably associated with future AD in men and women with MCI. Regarding CU participants, the following significant sex by NPS interactions were noted: female sex moderated the risk conferred by moderate/severe apathy (HR = 7.36, 3.25–16.64) by 74%, mitigated the risk conferred by moderate/severe depression (HR = 3.61, 2.08–6.28) by 52%, and augmented the risks conferred by mild depression (HR = 1.00, 0.60–1.68) and agitation (HR = 0.81, 0.40–1.64) by 83% and 243%, respectively. CONCLUSIONS: Apathy, depression and agitation were differentially associated with incident AD in CU men and women. No individual NPS was associated with different risks of future AD in men versus women with MCI. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s00415-022-11541-w. Springer Berlin Heidelberg 2022-12-26 2023 /pmc/articles/PMC10025238/ /pubmed/36572715 http://dx.doi.org/10.1007/s00415-022-11541-w Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Original Communication
Liampas, Ioannis
Siokas, Vasileios
Lyketsos, Constantine G.
Dardiotis, Efthimios
Associations between neuropsychiatric symptoms and incident Alzheimer’s dementia in men versus women
title Associations between neuropsychiatric symptoms and incident Alzheimer’s dementia in men versus women
title_full Associations between neuropsychiatric symptoms and incident Alzheimer’s dementia in men versus women
title_fullStr Associations between neuropsychiatric symptoms and incident Alzheimer’s dementia in men versus women
title_full_unstemmed Associations between neuropsychiatric symptoms and incident Alzheimer’s dementia in men versus women
title_short Associations between neuropsychiatric symptoms and incident Alzheimer’s dementia in men versus women
title_sort associations between neuropsychiatric symptoms and incident alzheimer’s dementia in men versus women
topic Original Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10025238/
https://www.ncbi.nlm.nih.gov/pubmed/36572715
http://dx.doi.org/10.1007/s00415-022-11541-w
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