Cargando…

Excretion kinetics of 1,3-dichlorobenzene and its urinary metabolites after controlled airborne exposure in human volunteers

The solvent 1,3-dichlorobenzene (1,3-DCB) is formed during thermal decomposition of the initiator 2,4-dichlorobenzoylperoxide in the production of silicone rubber with potential exposure of production workers as shown in previous works. Despite a threshold limit value (MAK value) of 2 ppm in air, th...

Descripción completa

Detalles Bibliográficos
Autores principales:	Schettgen, T., Bertram, J., Krabbe, J., Christoforou, R., Schweiker, M., Esser, A., Möller, M., Ziegler, P., Kraus, T.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Berlin Heidelberg 2023
Materias:	Toxicokinetics and Metabolism
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10025240/ https://www.ncbi.nlm.nih.gov/pubmed/36717398 http://dx.doi.org/10.1007/s00204-023-03447-x

Ejemplares similares

New data on the metabolism of chloromethylisothiazolinone and methylisothiazolinone in human volunteers after oral dosage: excretion kinetics of a urinary mercapturic acid metabolite (“M-12”)
por: Schettgen, Thomas, et al.
Publicado: (2021)

Human metabolism and excretion kinetics of benzotriazole UV stabilizer UV-327 after single oral administration
por: Fischer, Corinna, et al.
Publicado: (2022)

Human metabolism and urinary excretion of seven neonicotinoids and neonicotinoid-like compounds after controlled oral dosages
por: Wrobel, Sonja A., et al.
Publicado: (2021)

Novel testing strategy for prediction of rat biliary excretion of intravenously administered estradiol-17β glucuronide
por: Noorlander, Annelies, et al.
Publicado: (2020)

Physiologically based kinetic modeling of the bioactivation of myristicin
por: Al-Malahmeh, Amer J., et al.
Publicado: (2016)

A novel approach to calculating the kinetically derived maximum dose
por: Burgoon, Lyle D., et al.
Publicado: (2022)

Inter-individual variation in chlorpyrifos toxicokinetics characterized by physiologically based kinetic (PBK) and Monte Carlo simulation comparing human liver microsome and Supersome(™) cytochromes P450 (CYP)-specific kinetic data as model input
por: Zhao, Shensheng, et al.
Publicado: (2022)

Study on inter-ethnic human differences in bioactivation and detoxification of estragole using physiologically based kinetic modeling
por: Ning, Jia, et al.
Publicado: (2017)

The formation of estrogen-like tamoxifen metabolites and their influence on enzyme activity and gene expression of ADME genes
por: Johänning, Janina, et al.
Publicado: (2017)

Integrating in vitro data and physiologically based kinetic (PBK) modelling to assess the in vivo potential developmental toxicity of a series of phenols
por: Strikwold, Marije, et al.
Publicado: (2016)

Physiologically based kinetic modelling based prediction of in vivo rat and human acetylcholinesterase (AChE) inhibition upon exposure to diazinon
por: Zhao, Shensheng, et al.
Publicado: (2021)

Physiologically based kinetic modelling predicts the in vivo relative potency of riddelliine N-oxide compared to riddelliine in rat to be dose dependent
por: Widjaja, Frances, et al.
Publicado: (2021)

Towards a generic physiologically based kinetic model to predict in vivo uterotrophic responses in rats by reverse dosimetry of in vitro estrogenicity data
por: Zhang, Mengying, et al.
Publicado: (2017)

Prediction of dose-dependent in vivo acetylcholinesterase inhibition by profenofos in rats and humans using physiologically based kinetic (PBK) modeling-facilitated reverse dosimetry
por: Omwenga, Isaac, et al.
Publicado: (2021)

In vitro biotransformation of pyrrolizidine alkaloids in different species: part II—identification and quantitative assessment of the metabolite profile of six structurally different pyrrolizidine alkaloids
por: Geburek, Ina, et al.
Publicado: (2020)

Human metabolism and kinetics of the UV absorber 2-(2H-benzotriazol-2-yl)-4,6-di-tert-pentylphenol (UV 328) after oral administration
por: Denghel, Heike, et al.
Publicado: (2021)

Glucuronidation of deoxynivalenol (DON) by different animal species: identification of iso-DON glucuronides and iso-deepoxy-DON glucuronides as novel DON metabolites in pigs, rats, mice, and cows
por: Schwartz-Zimmermann, Heidi E., et al.
Publicado: (2017)

Toxicokinetics of U-47700, tramadol, and their main metabolites in pigs following intravenous administration: is a multiple species allometric scaling approach useful for the extrapolation of toxicokinetic parameters to humans?
por: Nordmeier, Frederike, et al.
Publicado: (2021)

In vivo and ex vivo percutaneous absorption of [(14)C]-bisphenol A in rats: a possible extrapolation to human absorption?
por: Marquet, Fabrice, et al.
Publicado: (2011)

Bioavailability of cyanide after consumption of a single meal of foods containing high levels of cyanogenic glycosides: a crossover study in humans
por: Abraham, Klaus, et al.
Publicado: (2015)

The impact of p53 on DNA damage and metabolic activation of the environmental carcinogen benzo[a]pyrene: effects in Trp53(+/+), Trp53(+/–) and Trp53(−/−) mice
por: Krais, Annette M., et al.
Publicado: (2015)

Carcinogenic polycyclic aromatic hydrocarbons induce CYP1A1 in human cells via a p53-dependent mechanism
por: Wohak, Laura E., et al.
Publicado: (2014)

Bioactivation of food genotoxicants 5-hydroxymethylfurfural and furfuryl alcohol by sulfotransferases from human, mouse and rat: a comparative study
por: Sachse, Benjamin, et al.
Publicado: (2014)

Genetic enhancement of microsomal epoxide hydrolase improves metabolic detoxification but impairs cerebral blood flow regulation
por: Marowsky, Anne, et al.
Publicado: (2016)

In vitro biotransformation of pyrrolizidine alkaloids in different species. Part I: Microsomal degradation
por: Kolrep, Franziska, et al.
Publicado: (2017)

Beyond detoxification: a role for mouse mEH in the hepatic metabolism of endogenous lipids
por: Marowsky, Anne, et al.
Publicado: (2017)

Quantification of N-phenyl-2-naphthylamine by gas chromatography and isotope-dilution mass spectrometry and its percutaneous absorption ex vivo under workplace conditions
por: Marek, Eike Maximilian, et al.
Publicado: (2017)

Biomarker monitoring of controlled dietary acrylamide exposure indicates consistent human endogenous background
por: Goempel, Katharina, et al.
Publicado: (2017)

Evidence for a complex formation between CYP2J5 and mEH in living cells by FRET analysis of membrane protein interaction in the endoplasmic reticulum (FAMPIR)
por: Orjuela Leon, Anette Carolina, et al.
Publicado: (2017)

The metabolic fate of fenclozic acid in chimeric mice with a humanized liver
por: Ekdahl, Anja, et al.
Publicado: (2018)

Correlations between metabolism and structural elements of the alicyclic fentanyl analogs cyclopropyl fentanyl, cyclobutyl fentanyl, cyclopentyl fentanyl, cyclohexyl fentanyl and 2,2,3,3-tetramethylcyclopropyl fentanyl studied by human hepatocytes and LC-QTOF-MS
por: Åstrand, Anna, et al.
Publicado: (2018)

Impact of phase I metabolism on uptake, oxidative stress and genotoxicity of the emerging mycotoxin alternariol and its monomethyl ether in esophageal cells
por: Tiessen, Christine, et al.
Publicado: (2016)

Toxification of polycyclic aromatic hydrocarbons by commensal bacteria from human skin
por: Sowada, Juliane, et al.
Publicado: (2017)

Acute liver effects, disposition and metabolic fate of [(14)C]-fenclozic acid following oral administration to normal and bile-cannulated male C57BL/6J mice
por: Pickup, Kathryn, et al.
Publicado: (2016)

Hair analysis for the biomonitoring of pesticide exposure: comparison with blood and urine in a rat model
por: Appenzeller, Brice M. R., et al.
Publicado: (2016)

Long-term accumulation of diphenylarsinic acid in the central nervous system of cynomolgus monkeys
por: Masuda, Tomoyuki, et al.
Publicado: (2017)

Maintenance of drug metabolism and transport functions in human precision-cut liver slices during prolonged incubation for 5 days
por: Starokozhko, Viktoriia, et al.
Publicado: (2016)

Xenobiotic metabolism in differentiated human bronchial epithelial cells
por: Boei, Jan J. W. A., et al.
Publicado: (2016)

Determination of aflatoxin M(1) and deoxynivalenol biomarkers in infants and children urines from Bangladesh
por: Ali, Nurshad, et al.
Publicado: (2020)

Influence of breast cancer risk factors and intramammary biotransformation on estrogen homeostasis in the human breast
por: Pemp, Daniela, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_d6j0but8kqfs25s15lar3lvpau