Preparing glycomics data for robust statistical analysis with GlyCompareCT

GlyCompareCT is a portable command-line tool to facilitate downstream glycomic data analyses, by addressing data inherent sparsity and non-independence. Inputting glycan abundances, users can run GlyCompareCT with one line of code to obtain the abundances of a minimal substructure set, named glycomo...

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Detalles Bibliográficos
Autores principales: Zhang, Yujie, Krishnan, Sridevi, Bao, Bokan, Chiang, Austin W.T., Sorrentino, James T., Schinn, Song-Min, Kellman, Benjamin P., Lewis, Nathan E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Protocol
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10025275/
https://www.ncbi.nlm.nih.gov/pubmed/36920914
http://dx.doi.org/10.1016/j.xpro.2023.102162
Descripción
Sumario:GlyCompareCT is a portable command-line tool to facilitate downstream glycomic data analyses, by addressing data inherent sparsity and non-independence. Inputting glycan abundances, users can run GlyCompareCT with one line of code to obtain the abundances of a minimal substructure set, named glycomotif, thereby quantifying hidden biosynthetic relationships between measured glycans. Optional parameters tuning and annotation are supported for personal preference. For complete details on the use and execution of this protocol, please refer to Bao et al. (2021).(1)

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