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Deletion of the murine ortholog of human 9p21.3 locus promotes atherosclerosis by increasing macrophage proinflammatory activity

BACKGROUND: Several genome-wide association studies have reported a risk locus for coronary artery disease (CAD) in the 9p21. 3 chromosomal region. This region encodes a lncRNA in the INK4 locus (ANRIL) and its genetic variance has a strong association with CAD, but its mechanisms in atherogenesis r...

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Detalles Bibliográficos
Autores principales:	Kettunen, Sanna, Ruotsalainen, Anna-Kaisa, Örd, Tiit, Suoranta, Tuisku, Heikkilä, Janne, Kaikkonen, Minna U., Laham-Karam, Nihay, Ylä-Herttuala, Seppo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Cardiovascular Medicine
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10025322/ https://www.ncbi.nlm.nih.gov/pubmed/36950286 http://dx.doi.org/10.3389/fcvm.2023.1113890

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