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Helicobacter pylori infection increase the risk of subclinical hyperthyroidism in middle-aged and elderly women independent of dietary factors: Results from the Tianjin chronic low-grade systemic inflammation and health cohort study in China
BACKGROUND: Prospective studies on the association between Helicobacter pylori (H. pylori) infection and subclinical hyperthyroidism are limited. We, therefore, designed a large-scale cohort study to explore the association between H. pylori infection and the risk of subclinical hyperthyroidism in w...
Autores principales: | , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10025335/ https://www.ncbi.nlm.nih.gov/pubmed/36950328 http://dx.doi.org/10.3389/fnut.2023.1002359 |
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author | Zhang, Juanjuan Hai, Xinghua Wang, Siyu Zhu, Fan Gu, Yeqing Meng, Ge Zhang, Qing Liu, Li Wu, Hongmei Zhang, Shunming Zhang, Tingjing Wang, Xing Sun, Shaomei Zhou, Ming Jia, Qiyu Song, Kun Niu, Kaijun |
author_facet | Zhang, Juanjuan Hai, Xinghua Wang, Siyu Zhu, Fan Gu, Yeqing Meng, Ge Zhang, Qing Liu, Li Wu, Hongmei Zhang, Shunming Zhang, Tingjing Wang, Xing Sun, Shaomei Zhou, Ming Jia, Qiyu Song, Kun Niu, Kaijun |
author_sort | Zhang, Juanjuan |
collection | PubMed |
description | BACKGROUND: Prospective studies on the association between Helicobacter pylori (H. pylori) infection and subclinical hyperthyroidism are limited. We, therefore, designed a large-scale cohort study to explore the association between H. pylori infection and the risk of subclinical hyperthyroidism in women. METHODS: This prospective cohort study investigated 2,713 participants. H. pylori infection was diagnosed with the carbon 13 breath test. Subclinical hyperthyroidism was defined as serum thyroid-stimulating hormone levels are low or undetectable but free thyroxine and tri-iodothyronine concentrations are normal. Propensity score matching (PSM) analyses and Cox proportional hazards regression models were used to estimate the association between H. pylori infection and subclinical hyperthyroidism. RESULTS: A total of 1,025 PS-matched pairs of H. pylori infection women were generated after PSM. During 6 years of follow-up, the incidence rate of subclinical hyperthyroidism was 7.35/1,000 person-years. After adjusting potential confounding factors (including iodine intake in food and three main dietary patterns score), the multivariable hazard ratio (HR; 95% confidence intervals) of subclinical hyperthyroidism by H. pylori infection was 2.49 (1.36, 4.56). Stratified analyses suggested a potential effect modification by age, the multivariable HR (95% confidence intervals) was 2.85 (1.45, 5.61) in participants aged ≥ 40 years and 0.70 (0.08, 6.00) in participants aged < 40 years (P for interaction = 0.048). CONCLUSION: Our prospective study first indicates that H. pylori infection is significantly associated with the risk of subclinical hyperthyroidism independent of dietary factors among Chinese women, especially in middle-aged and older individuals. Clinical Trial Registration:https://upload.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000031137, identifier UMIN000027174. |
format | Online Article Text |
id | pubmed-10025335 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-100253352023-03-21 Helicobacter pylori infection increase the risk of subclinical hyperthyroidism in middle-aged and elderly women independent of dietary factors: Results from the Tianjin chronic low-grade systemic inflammation and health cohort study in China Zhang, Juanjuan Hai, Xinghua Wang, Siyu Zhu, Fan Gu, Yeqing Meng, Ge Zhang, Qing Liu, Li Wu, Hongmei Zhang, Shunming Zhang, Tingjing Wang, Xing Sun, Shaomei Zhou, Ming Jia, Qiyu Song, Kun Niu, Kaijun Front Nutr Nutrition BACKGROUND: Prospective studies on the association between Helicobacter pylori (H. pylori) infection and subclinical hyperthyroidism are limited. We, therefore, designed a large-scale cohort study to explore the association between H. pylori infection and the risk of subclinical hyperthyroidism in women. METHODS: This prospective cohort study investigated 2,713 participants. H. pylori infection was diagnosed with the carbon 13 breath test. Subclinical hyperthyroidism was defined as serum thyroid-stimulating hormone levels are low or undetectable but free thyroxine and tri-iodothyronine concentrations are normal. Propensity score matching (PSM) analyses and Cox proportional hazards regression models were used to estimate the association between H. pylori infection and subclinical hyperthyroidism. RESULTS: A total of 1,025 PS-matched pairs of H. pylori infection women were generated after PSM. During 6 years of follow-up, the incidence rate of subclinical hyperthyroidism was 7.35/1,000 person-years. After adjusting potential confounding factors (including iodine intake in food and three main dietary patterns score), the multivariable hazard ratio (HR; 95% confidence intervals) of subclinical hyperthyroidism by H. pylori infection was 2.49 (1.36, 4.56). Stratified analyses suggested a potential effect modification by age, the multivariable HR (95% confidence intervals) was 2.85 (1.45, 5.61) in participants aged ≥ 40 years and 0.70 (0.08, 6.00) in participants aged < 40 years (P for interaction = 0.048). CONCLUSION: Our prospective study first indicates that H. pylori infection is significantly associated with the risk of subclinical hyperthyroidism independent of dietary factors among Chinese women, especially in middle-aged and older individuals. Clinical Trial Registration:https://upload.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000031137, identifier UMIN000027174. Frontiers Media S.A. 2023-03-06 /pmc/articles/PMC10025335/ /pubmed/36950328 http://dx.doi.org/10.3389/fnut.2023.1002359 Text en Copyright © 2023 Zhang, Hai, Wang, Zhu, Gu, Meng, Zhang, Liu, Wu, Zhang, Zhang, Wang, Sun, Zhou, Jia, Song and Niu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Nutrition Zhang, Juanjuan Hai, Xinghua Wang, Siyu Zhu, Fan Gu, Yeqing Meng, Ge Zhang, Qing Liu, Li Wu, Hongmei Zhang, Shunming Zhang, Tingjing Wang, Xing Sun, Shaomei Zhou, Ming Jia, Qiyu Song, Kun Niu, Kaijun Helicobacter pylori infection increase the risk of subclinical hyperthyroidism in middle-aged and elderly women independent of dietary factors: Results from the Tianjin chronic low-grade systemic inflammation and health cohort study in China |
title | Helicobacter pylori infection increase the risk of subclinical hyperthyroidism in middle-aged and elderly women independent of dietary factors: Results from the Tianjin chronic low-grade systemic inflammation and health cohort study in China |
title_full | Helicobacter pylori infection increase the risk of subclinical hyperthyroidism in middle-aged and elderly women independent of dietary factors: Results from the Tianjin chronic low-grade systemic inflammation and health cohort study in China |
title_fullStr | Helicobacter pylori infection increase the risk of subclinical hyperthyroidism in middle-aged and elderly women independent of dietary factors: Results from the Tianjin chronic low-grade systemic inflammation and health cohort study in China |
title_full_unstemmed | Helicobacter pylori infection increase the risk of subclinical hyperthyroidism in middle-aged and elderly women independent of dietary factors: Results from the Tianjin chronic low-grade systemic inflammation and health cohort study in China |
title_short | Helicobacter pylori infection increase the risk of subclinical hyperthyroidism in middle-aged and elderly women independent of dietary factors: Results from the Tianjin chronic low-grade systemic inflammation and health cohort study in China |
title_sort | helicobacter pylori infection increase the risk of subclinical hyperthyroidism in middle-aged and elderly women independent of dietary factors: results from the tianjin chronic low-grade systemic inflammation and health cohort study in china |
topic | Nutrition |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10025335/ https://www.ncbi.nlm.nih.gov/pubmed/36950328 http://dx.doi.org/10.3389/fnut.2023.1002359 |
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