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Poly ADP-Ribose Polymerase-1 inhibition by 3-aminobenzamide recuperates HEI-OC1 auditory hair cells from blast overpressure-induced cell death

Introduction: Poly ADP-Ribose Polymerase-1 (PARP1), a DNA repair enzyme is implicated as a key molecule in the pathogenesis of several neurodegenerative disorders. Traumatic insults inducing oxidative stress results in its over-activation causing inflammation and cell death (Parthanatos). As PARP1 i...

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Detalles Bibliográficos
Autores principales:	Krishnan Muthaiah, Vijaya Prakash, Kaliyappan, Kathiravan, Mahajan, Supriya D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Cell and Developmental Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10025353/ https://www.ncbi.nlm.nih.gov/pubmed/36949771 http://dx.doi.org/10.3389/fcell.2023.1047308

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