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Dissecting insect cell heterogeneity during influenza VLP production using single-cell transcriptomics

The insect cell-baculovirus expression vector system (IC-BEVS) has been widely used to produce recombinant protein at high titers, including complex virus-like particles (VPLs). However, cell-to-cell variability upon infection is yet one of the least understood phenomena in virology, and little is k...

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Detalles Bibliográficos
Autores principales:	Silvano, Marco, Virgolini, Nikolaus, Correia, Ricardo, Clarke, Colin, Isidro, Inês A., Alves, Paula M., Roldão, António
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Bioengineering and Biotechnology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10025388/ https://www.ncbi.nlm.nih.gov/pubmed/36949887 http://dx.doi.org/10.3389/fbioe.2023.1143255

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