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Altered gut microbiota in the early stage of acute pancreatitis were related to the occurrence of acute respiratory distress syndrome
BACKGROUND: Acute respiratory distress syndrome (ARDS) is the most common cause of organ failure in acute pancreatitis (AP) patients, which associated with high mortality. Specific changes in the gut microbiota have been shown to influence progression of acute pancreatitis. We aimed to determine whe...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10025409/ https://www.ncbi.nlm.nih.gov/pubmed/36949815 http://dx.doi.org/10.3389/fcimb.2023.1127369 |
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author | Hu, Xiaomin Han, Ziying Zhou, Ruilin Su, Wan Gong, Liang Yang, Zihan Song, Xiao Zhang, Shuyang Shu, Huijun Wu, Dong |
author_facet | Hu, Xiaomin Han, Ziying Zhou, Ruilin Su, Wan Gong, Liang Yang, Zihan Song, Xiao Zhang, Shuyang Shu, Huijun Wu, Dong |
author_sort | Hu, Xiaomin |
collection | PubMed |
description | BACKGROUND: Acute respiratory distress syndrome (ARDS) is the most common cause of organ failure in acute pancreatitis (AP) patients, which associated with high mortality. Specific changes in the gut microbiota have been shown to influence progression of acute pancreatitis. We aimed to determine whether early alterations in the gut microbiota is related to and could predict ARDS occurrence in AP patients. METHODS: In this study, we performed 16S rRNA sequencing analysis in 65 AP patients and 20 healthy volunteers. The AP patients were further divided into two groups: 26 AP-ARDS patients and 39 AP-nonARDS patients based on ARDS occurrence during hospitalization. RESULTS: Our results showed that the AP-ARDS patients exhibited specific changes in gut microbiota composition and function as compared to subjects of AP-nonARDS group. Higher abundances of Proteobacteria phylum, Enterobacteriaceae family, Escherichia-Shigella genus, and Klebsiella pneumoniae, but lower abundances of Bifidobacterium genus were found in AP-ARDS group compared with AP-nonARDS groups. Random forest modelling analysis revealed that the Escherichia-shigella genus was effective to distinguish AP-ARDS from AP-nonARDS, which could predict ARDS occurrence in AP patients. CONCLUSIONS: Our study revealed that alterations of gut microbiota in AP patients on admission were associated with ARDS occurrence after hospitalization, indicating a potential predictive and pathogenic role of gut microbiota in the development of ARDS in AP patients. |
format | Online Article Text |
id | pubmed-10025409 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-100254092023-03-21 Altered gut microbiota in the early stage of acute pancreatitis were related to the occurrence of acute respiratory distress syndrome Hu, Xiaomin Han, Ziying Zhou, Ruilin Su, Wan Gong, Liang Yang, Zihan Song, Xiao Zhang, Shuyang Shu, Huijun Wu, Dong Front Cell Infect Microbiol Cellular and Infection Microbiology BACKGROUND: Acute respiratory distress syndrome (ARDS) is the most common cause of organ failure in acute pancreatitis (AP) patients, which associated with high mortality. Specific changes in the gut microbiota have been shown to influence progression of acute pancreatitis. We aimed to determine whether early alterations in the gut microbiota is related to and could predict ARDS occurrence in AP patients. METHODS: In this study, we performed 16S rRNA sequencing analysis in 65 AP patients and 20 healthy volunteers. The AP patients were further divided into two groups: 26 AP-ARDS patients and 39 AP-nonARDS patients based on ARDS occurrence during hospitalization. RESULTS: Our results showed that the AP-ARDS patients exhibited specific changes in gut microbiota composition and function as compared to subjects of AP-nonARDS group. Higher abundances of Proteobacteria phylum, Enterobacteriaceae family, Escherichia-Shigella genus, and Klebsiella pneumoniae, but lower abundances of Bifidobacterium genus were found in AP-ARDS group compared with AP-nonARDS groups. Random forest modelling analysis revealed that the Escherichia-shigella genus was effective to distinguish AP-ARDS from AP-nonARDS, which could predict ARDS occurrence in AP patients. CONCLUSIONS: Our study revealed that alterations of gut microbiota in AP patients on admission were associated with ARDS occurrence after hospitalization, indicating a potential predictive and pathogenic role of gut microbiota in the development of ARDS in AP patients. Frontiers Media S.A. 2023-03-06 /pmc/articles/PMC10025409/ /pubmed/36949815 http://dx.doi.org/10.3389/fcimb.2023.1127369 Text en Copyright © 2023 Hu, Han, Zhou, Su, Gong, Yang, Song, Zhang, Shu and Wu https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Cellular and Infection Microbiology Hu, Xiaomin Han, Ziying Zhou, Ruilin Su, Wan Gong, Liang Yang, Zihan Song, Xiao Zhang, Shuyang Shu, Huijun Wu, Dong Altered gut microbiota in the early stage of acute pancreatitis were related to the occurrence of acute respiratory distress syndrome |
title | Altered gut microbiota in the early stage of acute pancreatitis were related to the occurrence of acute respiratory distress syndrome |
title_full | Altered gut microbiota in the early stage of acute pancreatitis were related to the occurrence of acute respiratory distress syndrome |
title_fullStr | Altered gut microbiota in the early stage of acute pancreatitis were related to the occurrence of acute respiratory distress syndrome |
title_full_unstemmed | Altered gut microbiota in the early stage of acute pancreatitis were related to the occurrence of acute respiratory distress syndrome |
title_short | Altered gut microbiota in the early stage of acute pancreatitis were related to the occurrence of acute respiratory distress syndrome |
title_sort | altered gut microbiota in the early stage of acute pancreatitis were related to the occurrence of acute respiratory distress syndrome |
topic | Cellular and Infection Microbiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10025409/ https://www.ncbi.nlm.nih.gov/pubmed/36949815 http://dx.doi.org/10.3389/fcimb.2023.1127369 |
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