Polygoni Multiflori Radix interferes with bile acid metabolism homeostasis by inhibiting Fxr transcription, leading to cholestasis

Objective: To explore the possible mechanisms of cholestasis induced by Polygoni Multiflori Radix (PM). Methods: Low and high doses of water extract of PM were given to mice by gavage for 8 weeks. The serum biochemical indexes of aspartate aminotransferase (AST), alanine aminotransferase (ALT), glut...

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Detalles Bibliográficos
Autores principales: Dai, Yihang, Jia, Zhixin, Fang, Cong, Zhu, Meixia, Yan, Xiaoning, Zhang, Yinhuan, Wu, Hao, Feng, Menghan, Liu, Lirong, Huang, Beibei, Li, Yueting, Liu, Jie, Xiao, Hongbin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10025474/
https://www.ncbi.nlm.nih.gov/pubmed/36950015
http://dx.doi.org/10.3389/fphar.2023.1099935

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10025474/
https://www.ncbi.nlm.nih.gov/pubmed/36950015
http://dx.doi.org/10.3389/fphar.2023.1099935

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