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Altered topological properties of functional brain networks in patients with first episode, late-life depression before and after antidepressant treatment
OBJECTIVES: To preliminarily explore the functional activity and information integration of the brains under resting state based on graph theory in patients with first-episode, late-life depression (LLD) before and after antidepressant treatment. METHODS: A total of 50 patients with first-episode LL...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10025486/ https://www.ncbi.nlm.nih.gov/pubmed/36949772 http://dx.doi.org/10.3389/fnagi.2023.1107320 |
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author | Liu, Chaomeng Li, Li Pan, Weigang Zhu, Dandi Lian, Siyuan Liu, Yi Ren, Li Mao, Peixian Ren, Yanping Ma, Xin |
author_facet | Liu, Chaomeng Li, Li Pan, Weigang Zhu, Dandi Lian, Siyuan Liu, Yi Ren, Li Mao, Peixian Ren, Yanping Ma, Xin |
author_sort | Liu, Chaomeng |
collection | PubMed |
description | OBJECTIVES: To preliminarily explore the functional activity and information integration of the brains under resting state based on graph theory in patients with first-episode, late-life depression (LLD) before and after antidepressant treatment. METHODS: A total of 50 patients with first-episode LLD and 40 non-depressed controls (NCs) were recruited for the present research. Participants underwent the RBANS test, the 17-item Hamilton depression rating scale (HAMD-17) test, and resting-state functional MRI scans (rs-fMRI). The RBANS test consists of 12 sub-tests that contribute to a total score and index scores across the five domains: immediate memory, visuospatial/constructional, language, attention, and delayed memory. Escitalopram or sertraline was adopted for treating depression, and the dosage of the drug was adjusted by the experienced psychiatrists. Of the 50 LLD patients, 27 cases who completed 6-month follow-ups and 27 NCs matched with age, sex, and education level were included for the final statistical analysis. RESULTS: There were significant differences in RBANS total score, immediate memory, visuospatial/constructional, language, attention, and delayed memory between LLD baseline group and NCs group (P < 0.05). Considering the global attribute indicators, the clustering coefficient of global indicators was lower in the LLD baseline group than in the NCs group, and the small-world attribute of functional brain networks existed in all three groups. The degree centrality and node efficiency of some brains were lower in the LLD baseline group than in the NCs group. After 6 months of antidepressant therapy, the scores of HAMD-17, immediate memory, language, and delayed memory in the LLD follow-up group were higher than those in the LLD baseline group. Compared with the LLD baseline group, the degree centrality and node efficiency of some brains in the cognitive control network were decreased in the LLD follow-up group. CONCLUSIONS: The ability to integrate and divide labor of functional brain networks declines in LLD patients and linked with the depression severity. After the relief of depressive symptoms, the small-world attribute of functional brain networks in LLD patients persists. However, the information transmission efficiency and centrality of some brain regions continue to decline over time, perhaps related to their progressive cognitive impairment. |
format | Online Article Text |
id | pubmed-10025486 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-100254862023-03-21 Altered topological properties of functional brain networks in patients with first episode, late-life depression before and after antidepressant treatment Liu, Chaomeng Li, Li Pan, Weigang Zhu, Dandi Lian, Siyuan Liu, Yi Ren, Li Mao, Peixian Ren, Yanping Ma, Xin Front Aging Neurosci Aging Neuroscience OBJECTIVES: To preliminarily explore the functional activity and information integration of the brains under resting state based on graph theory in patients with first-episode, late-life depression (LLD) before and after antidepressant treatment. METHODS: A total of 50 patients with first-episode LLD and 40 non-depressed controls (NCs) were recruited for the present research. Participants underwent the RBANS test, the 17-item Hamilton depression rating scale (HAMD-17) test, and resting-state functional MRI scans (rs-fMRI). The RBANS test consists of 12 sub-tests that contribute to a total score and index scores across the five domains: immediate memory, visuospatial/constructional, language, attention, and delayed memory. Escitalopram or sertraline was adopted for treating depression, and the dosage of the drug was adjusted by the experienced psychiatrists. Of the 50 LLD patients, 27 cases who completed 6-month follow-ups and 27 NCs matched with age, sex, and education level were included for the final statistical analysis. RESULTS: There were significant differences in RBANS total score, immediate memory, visuospatial/constructional, language, attention, and delayed memory between LLD baseline group and NCs group (P < 0.05). Considering the global attribute indicators, the clustering coefficient of global indicators was lower in the LLD baseline group than in the NCs group, and the small-world attribute of functional brain networks existed in all three groups. The degree centrality and node efficiency of some brains were lower in the LLD baseline group than in the NCs group. After 6 months of antidepressant therapy, the scores of HAMD-17, immediate memory, language, and delayed memory in the LLD follow-up group were higher than those in the LLD baseline group. Compared with the LLD baseline group, the degree centrality and node efficiency of some brains in the cognitive control network were decreased in the LLD follow-up group. CONCLUSIONS: The ability to integrate and divide labor of functional brain networks declines in LLD patients and linked with the depression severity. After the relief of depressive symptoms, the small-world attribute of functional brain networks in LLD patients persists. However, the information transmission efficiency and centrality of some brain regions continue to decline over time, perhaps related to their progressive cognitive impairment. Frontiers Media S.A. 2023-03-06 /pmc/articles/PMC10025486/ /pubmed/36949772 http://dx.doi.org/10.3389/fnagi.2023.1107320 Text en Copyright © 2023 Liu, Li, Pan, Zhu, Lian, Liu, Ren, Mao, Ren and Ma. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Aging Neuroscience Liu, Chaomeng Li, Li Pan, Weigang Zhu, Dandi Lian, Siyuan Liu, Yi Ren, Li Mao, Peixian Ren, Yanping Ma, Xin Altered topological properties of functional brain networks in patients with first episode, late-life depression before and after antidepressant treatment |
title | Altered topological properties of functional brain networks in patients with first episode, late-life depression before and after antidepressant treatment |
title_full | Altered topological properties of functional brain networks in patients with first episode, late-life depression before and after antidepressant treatment |
title_fullStr | Altered topological properties of functional brain networks in patients with first episode, late-life depression before and after antidepressant treatment |
title_full_unstemmed | Altered topological properties of functional brain networks in patients with first episode, late-life depression before and after antidepressant treatment |
title_short | Altered topological properties of functional brain networks in patients with first episode, late-life depression before and after antidepressant treatment |
title_sort | altered topological properties of functional brain networks in patients with first episode, late-life depression before and after antidepressant treatment |
topic | Aging Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10025486/ https://www.ncbi.nlm.nih.gov/pubmed/36949772 http://dx.doi.org/10.3389/fnagi.2023.1107320 |
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