Neuronal protein interaction networks in autism spectrum disorder

How rare protein-disrupting risk variants implicated in autism spectrum disorders (ASDs) interact or functionally converge is unknown. Pintacuda et al.(1) perform proteomics in induced human neurons and identify more than 1,000 interactions, 90% of which were not previously reported, emphasizing the...

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Detalles Bibliográficos
Autores principales: Bicks, Lucy K., Eyring, Katherine Wade, Geschwind, Daniel H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10025519/
https://www.ncbi.nlm.nih.gov/pubmed/36950377
http://dx.doi.org/10.1016/j.xgen.2023.100279
Descripción
Sumario:How rare protein-disrupting risk variants implicated in autism spectrum disorders (ASDs) interact or functionally converge is unknown. Pintacuda et al.(1) perform proteomics in induced human neurons and identify more than 1,000 interactions, 90% of which were not previously reported, emphasizing the importance of cell-type- and isoform-specific protein interactions in ASD.

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