Neuronal protein interaction networks in autism spectrum disorder

How rare protein-disrupting risk variants implicated in autism spectrum disorders (ASDs) interact or functionally converge is unknown. Pintacuda et al.(1) perform proteomics in induced human neurons and identify more than 1,000 interactions, 90% of which were not previously reported, emphasizing the...

Descripción completa

Detalles Bibliográficos
Autores principales: Bicks, Lucy K., Eyring, Katherine Wade, Geschwind, Daniel H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Preview
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10025519/
https://www.ncbi.nlm.nih.gov/pubmed/36950377
http://dx.doi.org/10.1016/j.xgen.2023.100279
_version_ 1784909351293550592
author Bicks, Lucy K.
Eyring, Katherine Wade
Geschwind, Daniel H.
author_facet Bicks, Lucy K.
Eyring, Katherine Wade
Geschwind, Daniel H.
author_sort Bicks, Lucy K.
collection PubMed
description How rare protein-disrupting risk variants implicated in autism spectrum disorders (ASDs) interact or functionally converge is unknown. Pintacuda et al.(1) perform proteomics in induced human neurons and identify more than 1,000 interactions, 90% of which were not previously reported, emphasizing the importance of cell-type- and isoform-specific protein interactions in ASD.
format Online
Article
Text
id pubmed-10025519
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Elsevier
record_format MEDLINE/PubMed
spelling pubmed-100255192023-03-21 Neuronal protein interaction networks in autism spectrum disorder Bicks, Lucy K. Eyring, Katherine Wade Geschwind, Daniel H. Cell Genom Preview How rare protein-disrupting risk variants implicated in autism spectrum disorders (ASDs) interact or functionally converge is unknown. Pintacuda et al.(1) perform proteomics in induced human neurons and identify more than 1,000 interactions, 90% of which were not previously reported, emphasizing the importance of cell-type- and isoform-specific protein interactions in ASD. Elsevier 2023-03-08 /pmc/articles/PMC10025519/ /pubmed/36950377 http://dx.doi.org/10.1016/j.xgen.2023.100279 Text en © 2023 The Author(s) https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Preview
Bicks, Lucy K.
Eyring, Katherine Wade
Geschwind, Daniel H.
Neuronal protein interaction networks in autism spectrum disorder
title Neuronal protein interaction networks in autism spectrum disorder
title_full Neuronal protein interaction networks in autism spectrum disorder
title_fullStr Neuronal protein interaction networks in autism spectrum disorder
title_full_unstemmed Neuronal protein interaction networks in autism spectrum disorder
title_short Neuronal protein interaction networks in autism spectrum disorder
title_sort neuronal protein interaction networks in autism spectrum disorder
topic Preview
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10025519/
https://www.ncbi.nlm.nih.gov/pubmed/36950377
http://dx.doi.org/10.1016/j.xgen.2023.100279
work_keys_str_mv AT bickslucyk neuronalproteininteractionnetworksinautismspectrumdisorder
AT eyringkatherinewade neuronalproteininteractionnetworksinautismspectrumdisorder
AT geschwinddanielh neuronalproteininteractionnetworksinautismspectrumdisorder

Ejemplares similares