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The causal relationship between COVID-19 and increased intraocular pressure: A bidirectional two-sample Mendelian randomization study

BACKGROUND: Coronavirus disease 2019 (COVID-19) has brought great challenges to the global public health system and huge economic burdens to society, the causal effect of COVID-19 and intraocular pressure was blank. OBJECTIVE: This study aimed to explore the causal association between coronavirus di...

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Autores principales: Lin, Yi, Jiang, Bingcai, Cai, Yuanqing, Luo, Wangdu, Zheng, Changwei, Zhu, Xiaomin, Lin, Qianyi, Tang, Min, Li, Xiangji, Xie, Lin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10025528/
https://www.ncbi.nlm.nih.gov/pubmed/36950097
http://dx.doi.org/10.3389/fpubh.2023.1039290
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author Lin, Yi
Jiang, Bingcai
Cai, Yuanqing
Luo, Wangdu
Zheng, Changwei
Zhu, Xiaomin
Lin, Qianyi
Tang, Min
Li, Xiangji
Xie, Lin
author_facet Lin, Yi
Jiang, Bingcai
Cai, Yuanqing
Luo, Wangdu
Zheng, Changwei
Zhu, Xiaomin
Lin, Qianyi
Tang, Min
Li, Xiangji
Xie, Lin
author_sort Lin, Yi
collection PubMed
description BACKGROUND: Coronavirus disease 2019 (COVID-19) has brought great challenges to the global public health system and huge economic burdens to society, the causal effect of COVID-19 and intraocular pressure was blank. OBJECTIVE: This study aimed to explore the causal association between coronavirus disease (COVID-19) susceptibility, severity and criticality and intraocular pressure (IOP) by bidirectional Mendelian randomization (MR) analysis. MATERIALS AND METHODS: Genetic associations with COVID-19 susceptibility, severity and criticality were obtained from the COVID-19 Host Genetics Initiative. Genetic associations with IOP were obtained from GWAS summary data. The standard inverse variance weighted (IVW) method was used in the primary assessment of this causality. Other methods were also implemented in supplementary analyses. Finally, sensitivity analysis was performed to evaluate the reliability and stability of the results. RESULTS: The results showed that COVID-19 susceptibility had null effect on IOP (β = 0.131; Se = 0.211; P = 0.533) as assessed by the IVW method. Moreover, the results revealed that COVID-19 severity, specifically, hospitalization due to COVID-19, had a positive effect on IOP with nominal significance (β = 0.228; Se = 0.116; P = 0.049). However, there were null effect of COVID-19 criticality on IOP (β = 0.078; Se = 0.065; P = 0.227). Sensitivity analysis showed that all the results were reliable and stable. The reverse MR analysis revealed that there was null effect of IOP on COVID-19. CONCLUSIONS: We demonstrated that hospitalization due to COVID-19 might increase IOP; therefore, greater attention should be given to monitoring IOP in inpatients with COVID-19.
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spelling pubmed-100255282023-03-21 The causal relationship between COVID-19 and increased intraocular pressure: A bidirectional two-sample Mendelian randomization study Lin, Yi Jiang, Bingcai Cai, Yuanqing Luo, Wangdu Zheng, Changwei Zhu, Xiaomin Lin, Qianyi Tang, Min Li, Xiangji Xie, Lin Front Public Health Public Health BACKGROUND: Coronavirus disease 2019 (COVID-19) has brought great challenges to the global public health system and huge economic burdens to society, the causal effect of COVID-19 and intraocular pressure was blank. OBJECTIVE: This study aimed to explore the causal association between coronavirus disease (COVID-19) susceptibility, severity and criticality and intraocular pressure (IOP) by bidirectional Mendelian randomization (MR) analysis. MATERIALS AND METHODS: Genetic associations with COVID-19 susceptibility, severity and criticality were obtained from the COVID-19 Host Genetics Initiative. Genetic associations with IOP were obtained from GWAS summary data. The standard inverse variance weighted (IVW) method was used in the primary assessment of this causality. Other methods were also implemented in supplementary analyses. Finally, sensitivity analysis was performed to evaluate the reliability and stability of the results. RESULTS: The results showed that COVID-19 susceptibility had null effect on IOP (β = 0.131; Se = 0.211; P = 0.533) as assessed by the IVW method. Moreover, the results revealed that COVID-19 severity, specifically, hospitalization due to COVID-19, had a positive effect on IOP with nominal significance (β = 0.228; Se = 0.116; P = 0.049). However, there were null effect of COVID-19 criticality on IOP (β = 0.078; Se = 0.065; P = 0.227). Sensitivity analysis showed that all the results were reliable and stable. The reverse MR analysis revealed that there was null effect of IOP on COVID-19. CONCLUSIONS: We demonstrated that hospitalization due to COVID-19 might increase IOP; therefore, greater attention should be given to monitoring IOP in inpatients with COVID-19. Frontiers Media S.A. 2023-03-06 /pmc/articles/PMC10025528/ /pubmed/36950097 http://dx.doi.org/10.3389/fpubh.2023.1039290 Text en Copyright © 2023 Lin, Jiang, Cai, Luo, Zheng, Zhu, Lin, Tang, Li and Xie. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Public Health
Lin, Yi
Jiang, Bingcai
Cai, Yuanqing
Luo, Wangdu
Zheng, Changwei
Zhu, Xiaomin
Lin, Qianyi
Tang, Min
Li, Xiangji
Xie, Lin
The causal relationship between COVID-19 and increased intraocular pressure: A bidirectional two-sample Mendelian randomization study
title The causal relationship between COVID-19 and increased intraocular pressure: A bidirectional two-sample Mendelian randomization study
title_full The causal relationship between COVID-19 and increased intraocular pressure: A bidirectional two-sample Mendelian randomization study
title_fullStr The causal relationship between COVID-19 and increased intraocular pressure: A bidirectional two-sample Mendelian randomization study
title_full_unstemmed The causal relationship between COVID-19 and increased intraocular pressure: A bidirectional two-sample Mendelian randomization study
title_short The causal relationship between COVID-19 and increased intraocular pressure: A bidirectional two-sample Mendelian randomization study
title_sort causal relationship between covid-19 and increased intraocular pressure: a bidirectional two-sample mendelian randomization study
topic Public Health
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10025528/
https://www.ncbi.nlm.nih.gov/pubmed/36950097
http://dx.doi.org/10.3389/fpubh.2023.1039290
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