A strategy for the treatment of gastrointestinal cancer: Targeting tumor senescent cells

Gastrointestinal (GI) cancer includes a variety of cancers with high incidence that seriously threaten the lives of people worldwide. Although treatment strategies continue to improve, patient benefits are still very limited, and the ongoing search for new treatment strategies remains a priority. Ce...

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Detalles Bibliográficos
Autores principales: Liu, Yujing, Zhang, Qiang, Ni, Wenjing, Ji, Guang, Xu, Hanchen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Molecular Biosciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10025555/
https://www.ncbi.nlm.nih.gov/pubmed/36950520
http://dx.doi.org/10.3389/fmolb.2023.1139840
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author Liu, Yujing
Zhang, Qiang
Ni, Wenjing
Ji, Guang
Xu, Hanchen
author_facet Liu, Yujing
Zhang, Qiang
Ni, Wenjing
Ji, Guang
Xu, Hanchen
author_sort Liu, Yujing
collection PubMed
description Gastrointestinal (GI) cancer includes a variety of cancers with high incidence that seriously threaten the lives of people worldwide. Although treatment strategies continue to improve, patient benefits are still very limited, and the ongoing search for new treatment strategies remains a priority. Cell senescence is closely related to the occurrence and development of tumors. For GI cancer, cell senescence may not only promote cancer but also bring new opportunities for treatment. Combined with relevant studies, we review the dual role of cell senescence in GI cancer, including the mechanism of inducing cell senescence, biomarkers of senescent cells, and potential of targeted senescence therapy for GI cancer.
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spelling pubmed-100255552023-03-21 A strategy for the treatment of gastrointestinal cancer: Targeting tumor senescent cells Liu, Yujing Zhang, Qiang Ni, Wenjing Ji, Guang Xu, Hanchen Front Mol Biosci Molecular Biosciences Gastrointestinal (GI) cancer includes a variety of cancers with high incidence that seriously threaten the lives of people worldwide. Although treatment strategies continue to improve, patient benefits are still very limited, and the ongoing search for new treatment strategies remains a priority. Cell senescence is closely related to the occurrence and development of tumors. For GI cancer, cell senescence may not only promote cancer but also bring new opportunities for treatment. Combined with relevant studies, we review the dual role of cell senescence in GI cancer, including the mechanism of inducing cell senescence, biomarkers of senescent cells, and potential of targeted senescence therapy for GI cancer. Frontiers Media S.A. 2023-03-06 /pmc/articles/PMC10025555/ /pubmed/36950520 http://dx.doi.org/10.3389/fmolb.2023.1139840 Text en Copyright © 2023 Liu, Zhang, Ni, Ji and Xu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Molecular Biosciences
Liu, Yujing
Zhang, Qiang
Ni, Wenjing
Ji, Guang
Xu, Hanchen
A strategy for the treatment of gastrointestinal cancer: Targeting tumor senescent cells
title A strategy for the treatment of gastrointestinal cancer: Targeting tumor senescent cells
title_full A strategy for the treatment of gastrointestinal cancer: Targeting tumor senescent cells
title_fullStr A strategy for the treatment of gastrointestinal cancer: Targeting tumor senescent cells
title_full_unstemmed A strategy for the treatment of gastrointestinal cancer: Targeting tumor senescent cells
title_short A strategy for the treatment of gastrointestinal cancer: Targeting tumor senescent cells
title_sort strategy for the treatment of gastrointestinal cancer: targeting tumor senescent cells
topic Molecular Biosciences
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10025555/
https://www.ncbi.nlm.nih.gov/pubmed/36950520
http://dx.doi.org/10.3389/fmolb.2023.1139840
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