In vivo interrogation of regulatory genomes reveals extensive quasi-insufficiency in cancer evolution

In contrast to mono- or biallelic loss of tumor-suppressor function, effects of discrete gene dysregulations, as caused by non-coding (epi)genome alterations, are poorly understood. Here, by perturbing the regulatory genome in mice, we uncover pervasive roles of subtle gene expression variation in c...

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Detalles Bibliográficos
Autores principales: Fischer, Anja, Lersch, Robert, de Andrade Krätzig, Niklas, Strong, Alexander, Friedrich, Mathias J., Weber, Julia, Engleitner, Thomas, Öllinger, Rupert, Yen, Hsi-Yu, Kohlhofer, Ursula, Gonzalez-Menendez, Irene, Sailer, David, Kogan, Liz, Lahnalampi, Mari, Laukkanen, Saara, Kaltenbacher, Thorsten, Klement, Christine, Rezaei, Majdaddin, Ammon, Tim, Montero, Juan J., Schneider, Günter, Mayerle, Julia, Heikenwälder, Mathias, Schmidt-Supprian, Marc, Quintanilla-Martinez, Leticia, Steiger, Katja, Liu, Pentao, Cadiñanos, Juan, Vassiliou, George S., Saur, Dieter, Lohi, Olli, Heinäniemi, Merja, Conte, Nathalie, Bradley, Allan, Rad, Lena, Rad, Roland
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10025556/
https://www.ncbi.nlm.nih.gov/pubmed/36950387
http://dx.doi.org/10.1016/j.xgen.2023.100276

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