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Serum uric acid: A risk factor for right ventricular dysfunction and prognosis in heart failure with preserved ejection fraction

BACKGROUND: Hyperuricemia and right ventricular dysfunction (RVD) are both widespread in heart failure with preserved ejection fraction (HFpEF) patients. RVD is associated with a poor prognosis in HFpEF. The correlation between serum uric acid (UA) levels and right ventricular function is unclear. T...

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Autores principales: Deng, Xiang-liang, Yi, Han-wen, Xiao, Jin, Zhang, Xiao-fang, Zhao, Jin, Sun, Min, Wen, Xue-song, Liu, Zhi-qiang, Gao, Lei, Li, Zi-yang, Ge, Ping, Yu, Qi, Zhang, Dong-ying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10025558/
https://www.ncbi.nlm.nih.gov/pubmed/36950688
http://dx.doi.org/10.3389/fendo.2023.1143458
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author Deng, Xiang-liang
Yi, Han-wen
Xiao, Jin
Zhang, Xiao-fang
Zhao, Jin
Sun, Min
Wen, Xue-song
Liu, Zhi-qiang
Gao, Lei
Li, Zi-yang
Ge, Ping
Yu, Qi
Zhang, Dong-ying
author_facet Deng, Xiang-liang
Yi, Han-wen
Xiao, Jin
Zhang, Xiao-fang
Zhao, Jin
Sun, Min
Wen, Xue-song
Liu, Zhi-qiang
Gao, Lei
Li, Zi-yang
Ge, Ping
Yu, Qi
Zhang, Dong-ying
author_sort Deng, Xiang-liang
collection PubMed
description BACKGROUND: Hyperuricemia and right ventricular dysfunction (RVD) are both widespread in heart failure with preserved ejection fraction (HFpEF) patients. RVD is associated with a poor prognosis in HFpEF. The correlation between serum uric acid (UA) levels and right ventricular function is unclear. The prognostic performance of UA in patients with HFpEF needs further validation. METHODS AND RESULTS: A total of 210 patients with HFpEF were included in the study and divided into two groups according to UA level: the normal UA group (≤7 mg/dl) and the high UA group (>7 mg/dl). The variables examined included clinical characteristics, echocardiography, and serum biochemical parameters. Right ventricular function was assessed by tricuspid annular plane systolic excursion (TAPSE) and tricuspid annular peak systolic velocity (TAPSV). Baseline characteristics were compared between the two groups, and the correlation between baseline UA and RVD was assessed using multifactorial binary logistic regression. Kaplan–Meier curves were used to describe all-cause mortality and heart failure readmission. Results showed that right ventricular function parameters were worse in the high UA group. After adjusting for UA, left ventricular posterior wall thickness (LVPWT), N-terminal B-type natriuretic peptide (NT-proBNP), atrial fibrillation (AF), and low-density lipoprotein cholesterol (LDL-C), UA (odds ratio = 2.028; p < 0.001) was independently associated with RVD, and UA >7 mg/dl (HR = 2.98; p < 0.001) was associated with heart failure readmission in patients with HFpEF. CONCLUSION: Elevated serum UA is closely associated with RVD and significantly associated with the heart failure readmission rate in patients with HFpEF.
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spelling pubmed-100255582023-03-21 Serum uric acid: A risk factor for right ventricular dysfunction and prognosis in heart failure with preserved ejection fraction Deng, Xiang-liang Yi, Han-wen Xiao, Jin Zhang, Xiao-fang Zhao, Jin Sun, Min Wen, Xue-song Liu, Zhi-qiang Gao, Lei Li, Zi-yang Ge, Ping Yu, Qi Zhang, Dong-ying Front Endocrinol (Lausanne) Endocrinology BACKGROUND: Hyperuricemia and right ventricular dysfunction (RVD) are both widespread in heart failure with preserved ejection fraction (HFpEF) patients. RVD is associated with a poor prognosis in HFpEF. The correlation between serum uric acid (UA) levels and right ventricular function is unclear. The prognostic performance of UA in patients with HFpEF needs further validation. METHODS AND RESULTS: A total of 210 patients with HFpEF were included in the study and divided into two groups according to UA level: the normal UA group (≤7 mg/dl) and the high UA group (>7 mg/dl). The variables examined included clinical characteristics, echocardiography, and serum biochemical parameters. Right ventricular function was assessed by tricuspid annular plane systolic excursion (TAPSE) and tricuspid annular peak systolic velocity (TAPSV). Baseline characteristics were compared between the two groups, and the correlation between baseline UA and RVD was assessed using multifactorial binary logistic regression. Kaplan–Meier curves were used to describe all-cause mortality and heart failure readmission. Results showed that right ventricular function parameters were worse in the high UA group. After adjusting for UA, left ventricular posterior wall thickness (LVPWT), N-terminal B-type natriuretic peptide (NT-proBNP), atrial fibrillation (AF), and low-density lipoprotein cholesterol (LDL-C), UA (odds ratio = 2.028; p < 0.001) was independently associated with RVD, and UA >7 mg/dl (HR = 2.98; p < 0.001) was associated with heart failure readmission in patients with HFpEF. CONCLUSION: Elevated serum UA is closely associated with RVD and significantly associated with the heart failure readmission rate in patients with HFpEF. Frontiers Media S.A. 2023-03-06 /pmc/articles/PMC10025558/ /pubmed/36950688 http://dx.doi.org/10.3389/fendo.2023.1143458 Text en Copyright © 2023 Deng, Yi, Xiao, Zhang, Zhao, Sun, Wen, Liu, Gao, Li, Ge, Yu and Zhang https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Deng, Xiang-liang
Yi, Han-wen
Xiao, Jin
Zhang, Xiao-fang
Zhao, Jin
Sun, Min
Wen, Xue-song
Liu, Zhi-qiang
Gao, Lei
Li, Zi-yang
Ge, Ping
Yu, Qi
Zhang, Dong-ying
Serum uric acid: A risk factor for right ventricular dysfunction and prognosis in heart failure with preserved ejection fraction
title Serum uric acid: A risk factor for right ventricular dysfunction and prognosis in heart failure with preserved ejection fraction
title_full Serum uric acid: A risk factor for right ventricular dysfunction and prognosis in heart failure with preserved ejection fraction
title_fullStr Serum uric acid: A risk factor for right ventricular dysfunction and prognosis in heart failure with preserved ejection fraction
title_full_unstemmed Serum uric acid: A risk factor for right ventricular dysfunction and prognosis in heart failure with preserved ejection fraction
title_short Serum uric acid: A risk factor for right ventricular dysfunction and prognosis in heart failure with preserved ejection fraction
title_sort serum uric acid: a risk factor for right ventricular dysfunction and prognosis in heart failure with preserved ejection fraction
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10025558/
https://www.ncbi.nlm.nih.gov/pubmed/36950688
http://dx.doi.org/10.3389/fendo.2023.1143458
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