Cargando…
Liver and Renal Injury with Remdesivir Treatment in SARS-CoV-2 Patients
OBJECTIVE: To determine the effect of Remdesivir on liver enzymes and renal functions in SARS-CoV-2 patients. METHODS: This prospective cohort study was conducted at Dr. Ruth KM Pfau, Civil Hospital Karachi between 1(st) December 2021 to 31(st) January, 2022. All patients of severe SARS-CoV-2 infect...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Professional Medical Publications
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10025697/ https://www.ncbi.nlm.nih.gov/pubmed/36950448 http://dx.doi.org/10.12669/pjms.39.2.6236 |
_version_ | 1784909392033873920 |
---|---|
author | Sadaf, Rabiah Ali, Faiza Sadaqat Rasheed, Tazeen Zuberi, Bader Faiyaz |
author_facet | Sadaf, Rabiah Ali, Faiza Sadaqat Rasheed, Tazeen Zuberi, Bader Faiyaz |
author_sort | Sadaf, Rabiah |
collection | PubMed |
description | OBJECTIVE: To determine the effect of Remdesivir on liver enzymes and renal functions in SARS-CoV-2 patients. METHODS: This prospective cohort study was conducted at Dr. Ruth KM Pfau, Civil Hospital Karachi between 1(st) December 2021 to 31(st) January, 2022. All patients of severe SARS-CoV-2 infection who received Inj. Remdesivir for five days as per protocol of SARS-CoV-2 management were included. Biodata of selected patients including age, gender, diabetic, hypertensive status was recorded. Patients Liver Function Tests and Serum Creatinine were performed on days 0, 3, 5, 7 and 14. RESULT: This study included 85 patients, out of which 55 (64.7%) were males and 30 (35.3%) were females. Out of 85 patients, Remdesivir was stopped in 3 (3.5%) patients. Among these three patients Remdesivir was stopped in one patient on day three because of decrease in CrCl to <30 ml/min. His CrCl improved after stopping Remdesivir. In the remaining two patients, Remdesivir was stopped due to increase in ALT to greater than 10 times from normal values on day three. Similarly, in these two patients the ALT improved after stopping Remdesivir. CONCLUSION: Only three patients developed adverse effects resulting in stopping of Remdesivir, however these were reversible on stopping the drug. Therefore, Remdesivir is a relatively safe drug and well tolerated in SARS-CoV-2 patients. |
format | Online Article Text |
id | pubmed-10025697 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Professional Medical Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-100256972023-03-21 Liver and Renal Injury with Remdesivir Treatment in SARS-CoV-2 Patients Sadaf, Rabiah Ali, Faiza Sadaqat Rasheed, Tazeen Zuberi, Bader Faiyaz Pak J Med Sci Original Article OBJECTIVE: To determine the effect of Remdesivir on liver enzymes and renal functions in SARS-CoV-2 patients. METHODS: This prospective cohort study was conducted at Dr. Ruth KM Pfau, Civil Hospital Karachi between 1(st) December 2021 to 31(st) January, 2022. All patients of severe SARS-CoV-2 infection who received Inj. Remdesivir for five days as per protocol of SARS-CoV-2 management were included. Biodata of selected patients including age, gender, diabetic, hypertensive status was recorded. Patients Liver Function Tests and Serum Creatinine were performed on days 0, 3, 5, 7 and 14. RESULT: This study included 85 patients, out of which 55 (64.7%) were males and 30 (35.3%) were females. Out of 85 patients, Remdesivir was stopped in 3 (3.5%) patients. Among these three patients Remdesivir was stopped in one patient on day three because of decrease in CrCl to <30 ml/min. His CrCl improved after stopping Remdesivir. In the remaining two patients, Remdesivir was stopped due to increase in ALT to greater than 10 times from normal values on day three. Similarly, in these two patients the ALT improved after stopping Remdesivir. CONCLUSION: Only three patients developed adverse effects resulting in stopping of Remdesivir, however these were reversible on stopping the drug. Therefore, Remdesivir is a relatively safe drug and well tolerated in SARS-CoV-2 patients. Professional Medical Publications 2023 /pmc/articles/PMC10025697/ /pubmed/36950448 http://dx.doi.org/10.12669/pjms.39.2.6236 Text en Copyright: © Pakistan Journal of Medical Sciences https://creativecommons.org/licenses/by/3.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0 (https://creativecommons.org/licenses/by/3.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Sadaf, Rabiah Ali, Faiza Sadaqat Rasheed, Tazeen Zuberi, Bader Faiyaz Liver and Renal Injury with Remdesivir Treatment in SARS-CoV-2 Patients |
title | Liver and Renal Injury with Remdesivir Treatment in SARS-CoV-2 Patients |
title_full | Liver and Renal Injury with Remdesivir Treatment in SARS-CoV-2 Patients |
title_fullStr | Liver and Renal Injury with Remdesivir Treatment in SARS-CoV-2 Patients |
title_full_unstemmed | Liver and Renal Injury with Remdesivir Treatment in SARS-CoV-2 Patients |
title_short | Liver and Renal Injury with Remdesivir Treatment in SARS-CoV-2 Patients |
title_sort | liver and renal injury with remdesivir treatment in sars-cov-2 patients |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10025697/ https://www.ncbi.nlm.nih.gov/pubmed/36950448 http://dx.doi.org/10.12669/pjms.39.2.6236 |
work_keys_str_mv | AT sadafrabiah liverandrenalinjurywithremdesivirtreatmentinsarscov2patients AT alifaizasadaqat liverandrenalinjurywithremdesivirtreatmentinsarscov2patients AT rasheedtazeen liverandrenalinjurywithremdesivirtreatmentinsarscov2patients AT zuberibaderfaiyaz liverandrenalinjurywithremdesivirtreatmentinsarscov2patients |