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Effect of low skeletal muscle mass on long-term mortality after abdominal aortic aneurysm repair: A meta-analysis

OBJECTIVE: This meta-analysis was designed to assess if pre-operative low skeletal muscle mass impacts mortality rates of patients undergoing abdominal aortic aneurysm (AAA) repair. METHODS: Datasets of PubMed, CENTRAL, ScienceDirect, Embase, and Google Scholar were searched from 1(st) January 1980...

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Autores principales: Chen, Junjing, Xia, Yanfen, Liu, Yi, Zhu, Huifang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Professional Medical Publications 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10025718/
https://www.ncbi.nlm.nih.gov/pubmed/36950390
http://dx.doi.org/10.12669/pjms.39.2.7366
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author Chen, Junjing
Xia, Yanfen
Liu, Yi
Zhu, Huifang
author_facet Chen, Junjing
Xia, Yanfen
Liu, Yi
Zhu, Huifang
author_sort Chen, Junjing
collection PubMed
description OBJECTIVE: This meta-analysis was designed to assess if pre-operative low skeletal muscle mass impacts mortality rates of patients undergoing abdominal aortic aneurysm (AAA) repair. METHODS: Datasets of PubMed, CENTRAL, ScienceDirect, Embase, and Google Scholar were searched from 1(st) January 1980 to 15(th) December 2021 for studies assessing the role of low skeletal muscle mass on mortality rates of AAA repair. Studies measuring skeletal muscle mass on computed tomography scans and reporting long-term mortality (>1 year) were included. Multivariable adjusted ratios were combined in a random-effects model. RESULTS: Fifteen studies with 3776 patients were included. Meta-analysis showed a statistically significant increased risk of all-cause mortality in patients with low skeletal muscle mass (HR: 2.07 95% CI: 1.56, 2.74 I2=65% p<0.00001) as compared to normal muscle mass patients. Pooled data indicated that low skeletal muscle mass was associated with statistically significant increased risk of mortality in studies on endovascular repair (HR: 2.86 95% CI: 1.95, 4.20 I2=58% p<0.00001) as well as those including a mixed group of patients (HR: 1.39 95% CI: 1.06, 1.82 I2=31% p=0.02). CONCLUSION: Low skeletal muscle mass in AAA patients undergoing surgical repair is associated with increased risk of long-term mortality. Current evidence is limited by the retrospective nature of data and variability in defining and measuring low skeletal muscle mass. There is a need for future prospective studies defining the optimal cut-off of low skeletal muscle mass in different populations.
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spelling pubmed-100257182023-03-21 Effect of low skeletal muscle mass on long-term mortality after abdominal aortic aneurysm repair: A meta-analysis Chen, Junjing Xia, Yanfen Liu, Yi Zhu, Huifang Pak J Med Sci Original Article/Meta Analysis OBJECTIVE: This meta-analysis was designed to assess if pre-operative low skeletal muscle mass impacts mortality rates of patients undergoing abdominal aortic aneurysm (AAA) repair. METHODS: Datasets of PubMed, CENTRAL, ScienceDirect, Embase, and Google Scholar were searched from 1(st) January 1980 to 15(th) December 2021 for studies assessing the role of low skeletal muscle mass on mortality rates of AAA repair. Studies measuring skeletal muscle mass on computed tomography scans and reporting long-term mortality (>1 year) were included. Multivariable adjusted ratios were combined in a random-effects model. RESULTS: Fifteen studies with 3776 patients were included. Meta-analysis showed a statistically significant increased risk of all-cause mortality in patients with low skeletal muscle mass (HR: 2.07 95% CI: 1.56, 2.74 I2=65% p<0.00001) as compared to normal muscle mass patients. Pooled data indicated that low skeletal muscle mass was associated with statistically significant increased risk of mortality in studies on endovascular repair (HR: 2.86 95% CI: 1.95, 4.20 I2=58% p<0.00001) as well as those including a mixed group of patients (HR: 1.39 95% CI: 1.06, 1.82 I2=31% p=0.02). CONCLUSION: Low skeletal muscle mass in AAA patients undergoing surgical repair is associated with increased risk of long-term mortality. Current evidence is limited by the retrospective nature of data and variability in defining and measuring low skeletal muscle mass. There is a need for future prospective studies defining the optimal cut-off of low skeletal muscle mass in different populations. Professional Medical Publications 2023 /pmc/articles/PMC10025718/ /pubmed/36950390 http://dx.doi.org/10.12669/pjms.39.2.7366 Text en Copyright: © Pakistan Journal of Medical Sciences https://creativecommons.org/licenses/by/3.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0 (https://creativecommons.org/licenses/by/3.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article/Meta Analysis
Chen, Junjing
Xia, Yanfen
Liu, Yi
Zhu, Huifang
Effect of low skeletal muscle mass on long-term mortality after abdominal aortic aneurysm repair: A meta-analysis
title Effect of low skeletal muscle mass on long-term mortality after abdominal aortic aneurysm repair: A meta-analysis
title_full Effect of low skeletal muscle mass on long-term mortality after abdominal aortic aneurysm repair: A meta-analysis
title_fullStr Effect of low skeletal muscle mass on long-term mortality after abdominal aortic aneurysm repair: A meta-analysis
title_full_unstemmed Effect of low skeletal muscle mass on long-term mortality after abdominal aortic aneurysm repair: A meta-analysis
title_short Effect of low skeletal muscle mass on long-term mortality after abdominal aortic aneurysm repair: A meta-analysis
title_sort effect of low skeletal muscle mass on long-term mortality after abdominal aortic aneurysm repair: a meta-analysis
topic Original Article/Meta Analysis
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10025718/
https://www.ncbi.nlm.nih.gov/pubmed/36950390
http://dx.doi.org/10.12669/pjms.39.2.7366
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