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Pro-inflammatory and pro-resolving lipid mediators of inflammation in HIV: effect of aspirin intervention

BACKGROUND: Persons with HIV (PWH) have an increased risk of cardiovascular disease (CVD) compared to HIV-seronegative individuals (SN). Inflammation contributes to this risk but the role of lipid mediators, with central roles in inflammation, in HIV infection remain to be established; further aspir...

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Autores principales: Dalli, Jesmond, Kitch, Douglas, O'Brien, Meagan P., Hunt, Peter W., Funderburg, Nicholas, Moisi, Daniela, Gupta, Amita, Brown, Todd T., Tien, Phyllis C., Aberg, Judith A., Shivakoti, Rupak
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10025757/
https://www.ncbi.nlm.nih.gov/pubmed/36791659
http://dx.doi.org/10.1016/j.ebiom.2023.104468
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author Dalli, Jesmond
Kitch, Douglas
O'Brien, Meagan P.
Hunt, Peter W.
Funderburg, Nicholas
Moisi, Daniela
Gupta, Amita
Brown, Todd T.
Tien, Phyllis C.
Aberg, Judith A.
Shivakoti, Rupak
author_facet Dalli, Jesmond
Kitch, Douglas
O'Brien, Meagan P.
Hunt, Peter W.
Funderburg, Nicholas
Moisi, Daniela
Gupta, Amita
Brown, Todd T.
Tien, Phyllis C.
Aberg, Judith A.
Shivakoti, Rupak
author_sort Dalli, Jesmond
collection PubMed
description BACKGROUND: Persons with HIV (PWH) have an increased risk of cardiovascular disease (CVD) compared to HIV-seronegative individuals (SN). Inflammation contributes to this risk but the role of lipid mediators, with central roles in inflammation, in HIV infection remain to be established; further aspirin reduces CVD risk in the general population through production of some of these anti-inflammatory lipid mediators, but they have not been studied in PWH. METHODS: We evaluated the relationship between plasma lipid mediators (i.e. 50 lipid mediators including classic eicosanoids and specialized pro-resolving mediators (SPMs)) and HIV status; and the impact of aspirin in PWH on regulating these autacoids. Plasma samples were obtained from 110 PWH receiving antiretroviral therapy (ART) from a randomized trial of aspirin (ACTG-A5331) and 107 matched SN samples (MACS-WIHS Combined Cohort). FINDINGS: PWH had lower levels of arachidonic acid-derived pro-inflammatory prostaglandins (PGs: PGE(2) and PGD(2)) and thromboxanes (Tx: TxB(2)), and higher levels of select pro-resolving lipid mediators (e.g. RvD4 and MaR2(n−3 DPA)) compared to SN. At the interval tested, aspirin intervention was observed to reduced PGs and Tx, and while we did not observe an increase in aspirin triggered mediators, we observed the upregulation of other SPM in aspirin treated PWH, namely MaR2(n−3 DPA). INTERPRETATION: Together these observations demonstrate that plasma lipid mediators profiles, some with links to systemic inflammation and CVD risk, become altered in PWH. Furthermore, aspirin intervention did not increase levels of aspirin-triggered pro-resolving lipid mediators, consistent with other reports of an impaired aspirin response in PWH. FUNDING: 10.13039/100000002NIH.
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spelling pubmed-100257572023-03-21 Pro-inflammatory and pro-resolving lipid mediators of inflammation in HIV: effect of aspirin intervention Dalli, Jesmond Kitch, Douglas O'Brien, Meagan P. Hunt, Peter W. Funderburg, Nicholas Moisi, Daniela Gupta, Amita Brown, Todd T. Tien, Phyllis C. Aberg, Judith A. Shivakoti, Rupak eBioMedicine Articles BACKGROUND: Persons with HIV (PWH) have an increased risk of cardiovascular disease (CVD) compared to HIV-seronegative individuals (SN). Inflammation contributes to this risk but the role of lipid mediators, with central roles in inflammation, in HIV infection remain to be established; further aspirin reduces CVD risk in the general population through production of some of these anti-inflammatory lipid mediators, but they have not been studied in PWH. METHODS: We evaluated the relationship between plasma lipid mediators (i.e. 50 lipid mediators including classic eicosanoids and specialized pro-resolving mediators (SPMs)) and HIV status; and the impact of aspirin in PWH on regulating these autacoids. Plasma samples were obtained from 110 PWH receiving antiretroviral therapy (ART) from a randomized trial of aspirin (ACTG-A5331) and 107 matched SN samples (MACS-WIHS Combined Cohort). FINDINGS: PWH had lower levels of arachidonic acid-derived pro-inflammatory prostaglandins (PGs: PGE(2) and PGD(2)) and thromboxanes (Tx: TxB(2)), and higher levels of select pro-resolving lipid mediators (e.g. RvD4 and MaR2(n−3 DPA)) compared to SN. At the interval tested, aspirin intervention was observed to reduced PGs and Tx, and while we did not observe an increase in aspirin triggered mediators, we observed the upregulation of other SPM in aspirin treated PWH, namely MaR2(n−3 DPA). INTERPRETATION: Together these observations demonstrate that plasma lipid mediators profiles, some with links to systemic inflammation and CVD risk, become altered in PWH. Furthermore, aspirin intervention did not increase levels of aspirin-triggered pro-resolving lipid mediators, consistent with other reports of an impaired aspirin response in PWH. FUNDING: 10.13039/100000002NIH. Elsevier 2023-02-13 /pmc/articles/PMC10025757/ /pubmed/36791659 http://dx.doi.org/10.1016/j.ebiom.2023.104468 Text en © 2023 The Authors https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Articles
Dalli, Jesmond
Kitch, Douglas
O'Brien, Meagan P.
Hunt, Peter W.
Funderburg, Nicholas
Moisi, Daniela
Gupta, Amita
Brown, Todd T.
Tien, Phyllis C.
Aberg, Judith A.
Shivakoti, Rupak
Pro-inflammatory and pro-resolving lipid mediators of inflammation in HIV: effect of aspirin intervention
title Pro-inflammatory and pro-resolving lipid mediators of inflammation in HIV: effect of aspirin intervention
title_full Pro-inflammatory and pro-resolving lipid mediators of inflammation in HIV: effect of aspirin intervention
title_fullStr Pro-inflammatory and pro-resolving lipid mediators of inflammation in HIV: effect of aspirin intervention
title_full_unstemmed Pro-inflammatory and pro-resolving lipid mediators of inflammation in HIV: effect of aspirin intervention
title_short Pro-inflammatory and pro-resolving lipid mediators of inflammation in HIV: effect of aspirin intervention
title_sort pro-inflammatory and pro-resolving lipid mediators of inflammation in hiv: effect of aspirin intervention
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10025757/
https://www.ncbi.nlm.nih.gov/pubmed/36791659
http://dx.doi.org/10.1016/j.ebiom.2023.104468
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