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Hepatic ZBTB22-mediated detoxification ameliorates acetaminophen-induced liver injury by inhibiting pregnane X receptor signaling

Overdose acetaminophen (APAP) can cause acute liver injury (ALI), but the underlying mechanism remains undetermined. This study explored the role of hepatic Zinc Finger And BTB Domain Containing 22 (ZBTB22) in defense against APAP-mediated hepatotoxicity. The results showed that hepatic ZBTB22 expre...

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Detalles Bibliográficos
Autores principales:	Chen, Yingjian, Cui, Tianqi, Xiao, Shaorong, Li, Tianyao, Zhong, Yadi, Tang, Kaijia, Guo, Jingyi, Huang, Shangyi, Chen, Jiabing, Li, Jiayu, Wang, Qi, Huang, Jiawen, Pan, Huafeng, Gao, Yong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10025966/ https://www.ncbi.nlm.nih.gov/pubmed/36950116 http://dx.doi.org/10.1016/j.isci.2023.106318

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