Immunosuppression reduces rAAV2.5T neutralizing antibodies that limit efficacy following repeat dosing to ferret lungs

The efficacy of redosing the recombinant adeno-associated virus (rAAV) vector rAAV2.5T to ferret lung is limited by AAV neutralizing antibody (NAb) responses. While immunosuppression strategies have allowed for systemic rAAV repeat dosing, their utility for rAAV lung-directed gene therapy is largely...

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Detalles Bibliográficos
Autores principales: Tang, Yinghua, Fakhari, Shahab, Huntemann, Eric D., Feng, Zehua, Wu, Peipei, Feng, William Y., Lei, Junying, Yuan, Feng, Excoffon, Katherine J., Wang, Kai, Limberis, Maria P., Kolbeck, Roland, Yan, Ziying, Engelhardt, John F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10025970/
https://www.ncbi.nlm.nih.gov/pubmed/36950451
http://dx.doi.org/10.1016/j.omtm.2023.02.015

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