Cargando…

A pharmacokinetic drug–drug interaction study between rosuvastatin and emvododstat, a potent anti‐SARS‐CoV‐2 (COVID‐19) DHODH (dihydroorotate dehydrogenase) inhibitor

A therapeutic agent that targets both viral replication and the hyper‐reactive immune response would offer a highly desirable treatment for severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2; COVID‐19) management. Emvododstat (PTC299) was found to be a potent inhibitor of immunomodulatory a...

Descripción completa

Detalles Bibliográficos
Autores principales:	Morton, Terri L., Laskin, Oscar L., Kaushik, Diksha, Lee, Lucy, Ma, Jiyuan, Kristensen, Allan, O'Keefe, Kylie, Golden, Lee, Klein, Matthew, Kong, Ronald
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2023
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10026081/ https://www.ncbi.nlm.nih.gov/pubmed/36938928 http://dx.doi.org/10.1002/prp2.1076

Ejemplares similares

A clinical pharmacokinetic drug-drug interaction study between dextromethorphan and emvododstat, a potent anti-SARS-CoV-2 dihydroorotate dehydrogenase inhibitor
por: Morton, Terri L., et al.
Publicado: (2023)

Emvododstat, a Potent Dihydroorotate Dehydrogenase Inhibitor, Is Effective in Preclinical Models of Acute Myeloid Leukemia
por: Branstrom, Arthur, et al.
Publicado: (2022)

Babesia bovis Dihydroorotate Dehydrogenase (BboDHODH) is a Novel Molecular Target of Drug for Bovine Babesiosis
por: KAMYINGKIRD, Ketsarin, et al.
Publicado: (2013)

Exploitation of dihydroorotate dehydrogenase (DHODH) and p53 activation as therapeutic targets: A case study in polypharmacology
por: Ladds, Marcus J. G.W., et al.
Publicado: (2021)

Efficacy and safety of dihydroorotate dehydrogenase (DHODH) inhibitors “leflunomide” and “teriflunomide” in Covid-19: A narrative review
por: Kaur, Hardeep, et al.
Publicado: (2021)

Original 2-(3-Alkoxy-1H-pyrazol-1-yl)azines Inhibitors of Human Dihydroorotate Dehydrogenase (DHODH)
por: Lucas-Hourani, Marianne, et al.
Publicado: (2015)

Development of a Human Dihydroorotate Dehydrogenase (hDHODH) Pharma-Similarity Index Approach with Scaffold-Hopping Strategy for the Design of Novel Potential Inhibitors
por: Shih, Kuei-Chung, et al.
Publicado: (2014)

Structural insights into inhibition of the drug target dihydroorotate dehydrogenase by bacterial hydroxyalkylquinolines
por: Horwitz, Samantha M., et al.
Publicado: (2022)

Repurposed dihydroorotate dehydrogenase inhibitors with efficacy against drug-resistant Acinetobacter baumannii
por: Russo, Thomas A., et al.
Publicado: (2022)

Inhibition of mitochondrial complex III or dihydroorotate dehydrogenase (DHODH) triggers formation of poly(A)(+) RNA foci adjacent to nuclear speckles following activation of ATM (ataxia telangiectasia mutated)
por: Miyake, Shuntaro, et al.
Publicado: (2022)

Structural and Biochemical Features of Eimeria tenella Dihydroorotate Dehydrogenase, a Potential Drug Target
por: Sato, Dan, et al.
Publicado: (2020)

ASLAN003, a potent dihydroorotate dehydrogenase inhibitor for differentiation of acute myeloid leukemia
por: Zhou, Jianbiao, et al.
Publicado: (2019)

Identification of Collateral Sensitivity to Dihydroorotate Dehydrogenase Inhibitors in Plasmodium falciparum
por: Ross, Leila Saxby, et al.
Publicado: (2018)

Mysteries of partial dihydroorotate dehydrogenase inhibition and leukemia terminal differentiation
por: Saunthararajah, Yogen
Publicado: (2020)

Potential treatment of COVID-19 by inhibitors of human dihydroorotate dehydrogenase
por: Xu, Yechun, et al.
Publicado: (2020)

Identification of Dihydroorotate Dehydrogenase Inhibitors Using the Cell Painting Assay
por: Schölermann, Beate, et al.
Publicado: (2022)

Novel Dihydroorotate Dehydrogenase Inhibitors with Potent Interferon-Independent Antiviral Activity against Mammarenaviruses In Vitro
por: Kim, Yu-Jin, et al.
Publicado: (2020)

Fluorescence assay of dihydroorotate dehydrogenase that may become a cancer biomarker
por: Yin, Sheng, et al.
Publicado: (2017)

Isoxazolopyrimidine-Based Inhibitors of Plasmodium falciparum Dihydroorotate Dehydrogenase with Antimalarial Activity
por: Kokkonda, Sreekanth, et al.
Publicado: (2018)

Dihydroorotate dehydrogenase inhibition reveals metabolic vulnerability in chronic myeloid leukemia
por: Houshmand, Mohammad, et al.
Publicado: (2022)

Checkpoint kinase 1 inhibition sensitises transformed cells to dihydroorotate dehydrogenase inhibition
por: Arnould, Stéphanie, et al.
Publicado: (2017)

Discovery of Antimalarial Azetidine-2-carbonitriles That Inhibit P. falciparum Dihydroorotate Dehydrogenase
por: Maetani, Micah, et al.
Publicado: (2017)

Therapeutic targeting of both dihydroorotate dehydrogenase and nucleoside transport in MYCN-amplified neuroblastoma
por: Yu, Yajie, et al.
Publicado: (2021)

Combination of consensus and ensemble docking strategies for the discovery of human dihydroorotate dehydrogenase inhibitors
por: Chilingaryan, Garri, et al.
Publicado: (2021)

DHODH is an independent prognostic marker and potent therapeutic target in neuroblastoma
por: Olsen, Thale Kristin, et al.
Publicado: (2022)

Rational Design of Benzylidenehydrazinyl-Substituted Thiazole Derivatives as Potent Inhibitors of Human Dihydroorotate Dehydrogenase with in Vivo Anti-arthritic Activity
por: Li, Shiliang, et al.
Publicado: (2015)

Fluorine Modulates Species Selectivity in the Triazolopyrimidine Class of Plasmodium falciparum Dihydroorotate Dehydrogenase Inhibitors
por: Deng, Xiaoyi, et al.
Publicado: (2014)

Lipids Shape the Electron Acceptor-Binding Site of the Peripheral Membrane Protein Dihydroorotate Dehydrogenase
por: Costeira-Paulo, Joana, et al.
Publicado: (2018)

Pharmacological inhibition of dihydroorotate dehydrogenase induces apoptosis and differentiation in acute myeloid leukemia cells
por: Wu, Dang, et al.
Publicado: (2018)

Molecular docking analysis of Plasmodium falciparum dihydroorotate dehydrogenase towards the design of effective inhibitors
por: Owoloye, Afolabi, et al.
Publicado: (2020)

Identification of Human Dihydroorotate Dehydrogenase Inhibitor by a Pharmacophore-Based Virtual Screening Study
por: Galati, Salvatore, et al.
Publicado: (2022)

The target site of the novel fungicide quinofumelin, Pyricularia oryzae class II dihydroorotate dehydrogenase
por: Higashimura, Norikazu, et al.
Publicado: (2022)

Identification of a dihydroorotate dehydrogenase inhibitor that inhibits cancer cell growth by proteomic profiling
por: KAWATANI, MAKOTO, et al.
Publicado: (2023)

In Vitro Resistance Selections for Plasmodium falciparum Dihydroorotate Dehydrogenase Inhibitors Give Mutants with Multiple Point Mutations in the Drug-binding Site and Altered Growth
por: Ross, Leila S., et al.
Publicado: (2014)

Tetrahydro-2-naphthyl and 2-Indanyl Triazolopyrimidines Targeting Plasmodium falciparum Dihydroorotate Dehydrogenase Display Potent and Selective Antimalarial Activity
por: Kokkonda, Sreekanth, et al.
Publicado: (2016)

Design, synthesis, molecular modeling, and biological evaluation of acrylamide derivatives as potent inhibitors of human dihydroorotate dehydrogenase for the treatment of rheumatoid arthritis()
por: Zeng, Fanxun, et al.
Publicado: (2021)

A Novel Graph Neural Network Methodology to Investigate Dihydroorotate Dehydrogenase Inhibitors in Small Cell Lung Cancer
por: Zhi, Hong-Yi, et al.
Publicado: (2021)

DHODH and cancer: promising prospects to be explored
por: Zhou, Yue, et al.
Publicado: (2021)

The Role of Dihydroorotate Dehydrogenase in Apoptosis Induction in Response to Inhibition of the Mitochondrial Respiratory Chain Complex III
por: Khutornenko, A. A., et al.
Publicado: (2014)

Crystal structures of FMN‐bound and FMN‐free forms of dihydroorotate dehydrogenase from Trypanosoma brucei
por: Kubota, Tomomi, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_1vte94rihfap5fo82omu7l6q6s