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Development and Psychometric Properties of a New Brief, Yet Comprehensive, Behavioral Questionnaire for Huntington's Disease

BACKGROUND: Individuals with Huntington's disease (HD) experience motoric, cognitive, and psychiatric dysfunction. These difficulties can cause maladaptive behaviors that can be very distressing to family and caregivers. Capturing these behaviors in clinical and research settings is crucial. OB...

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Autores principales: Hughes, Shelby, Aboufadel, Sameer, Smirnova, Anna, Snell, Chase, Churchill, Emma, Hall, Andrew, Malcarne, Vanessa, Gilbert, Paul E., Corey‐Bloom, Jody
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10026282/
https://www.ncbi.nlm.nih.gov/pubmed/36949805
http://dx.doi.org/10.1002/mdc3.13661
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author Hughes, Shelby
Aboufadel, Sameer
Smirnova, Anna
Snell, Chase
Churchill, Emma
Hall, Andrew
Malcarne, Vanessa
Gilbert, Paul E.
Corey‐Bloom, Jody
author_facet Hughes, Shelby
Aboufadel, Sameer
Smirnova, Anna
Snell, Chase
Churchill, Emma
Hall, Andrew
Malcarne, Vanessa
Gilbert, Paul E.
Corey‐Bloom, Jody
author_sort Hughes, Shelby
collection PubMed
description BACKGROUND: Individuals with Huntington's disease (HD) experience motoric, cognitive, and psychiatric dysfunction. These difficulties can cause maladaptive behaviors that can be very distressing to family and caregivers. Capturing these behaviors in clinical and research settings is crucial. OBJECTIVES: To develop and evaluate the psychometric properties of an instrument that is brief, yet comprehensive, in assessing a broad range of behaviors in HD. METHODS: A pool of 30 items encompassing common behaviors in HD was generated. Items were scored on a 4‐point Likert scale ranging from completely disagree to completely agree, with higher scores indicating greater dysfunction. The self‐report measure was piloted on a small sample of individuals with HD. Reliability (test–retest, internal consistency) and validity (convergent, discriminant, criterion) were evaluated. RESULTS: The HD–Behavioral Questionnaire (HD‐BQ) demonstrated evidence for reliability with a test–retest correlation coefficient of r = 0.81 and an internal consistency of 0.96. Validity was established with evidence for good convergent, divergent, and criterion validity. A receiver operating characteristic curve showed that the HD‐BQ outperformed a similar commonly used measure in diagnostic capability of behaviors in HD. CONCLUSIONS: The HD‐BQ, a patient self‐report measure, was created to more fully explore behavioral issues that people with HD experience in response to limitations of commonly used instruments in the field. Psychometric evidence supports that the HD‐BQ is a valid and reliable instrument for the brief, yet comprehensive, assessment of problematic behaviors in HD.
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spelling pubmed-100262822023-03-21 Development and Psychometric Properties of a New Brief, Yet Comprehensive, Behavioral Questionnaire for Huntington's Disease Hughes, Shelby Aboufadel, Sameer Smirnova, Anna Snell, Chase Churchill, Emma Hall, Andrew Malcarne, Vanessa Gilbert, Paul E. Corey‐Bloom, Jody Mov Disord Clin Pract Research Articles BACKGROUND: Individuals with Huntington's disease (HD) experience motoric, cognitive, and psychiatric dysfunction. These difficulties can cause maladaptive behaviors that can be very distressing to family and caregivers. Capturing these behaviors in clinical and research settings is crucial. OBJECTIVES: To develop and evaluate the psychometric properties of an instrument that is brief, yet comprehensive, in assessing a broad range of behaviors in HD. METHODS: A pool of 30 items encompassing common behaviors in HD was generated. Items were scored on a 4‐point Likert scale ranging from completely disagree to completely agree, with higher scores indicating greater dysfunction. The self‐report measure was piloted on a small sample of individuals with HD. Reliability (test–retest, internal consistency) and validity (convergent, discriminant, criterion) were evaluated. RESULTS: The HD–Behavioral Questionnaire (HD‐BQ) demonstrated evidence for reliability with a test–retest correlation coefficient of r = 0.81 and an internal consistency of 0.96. Validity was established with evidence for good convergent, divergent, and criterion validity. A receiver operating characteristic curve showed that the HD‐BQ outperformed a similar commonly used measure in diagnostic capability of behaviors in HD. CONCLUSIONS: The HD‐BQ, a patient self‐report measure, was created to more fully explore behavioral issues that people with HD experience in response to limitations of commonly used instruments in the field. Psychometric evidence supports that the HD‐BQ is a valid and reliable instrument for the brief, yet comprehensive, assessment of problematic behaviors in HD. John Wiley & Sons, Inc. 2023-02-02 /pmc/articles/PMC10026282/ /pubmed/36949805 http://dx.doi.org/10.1002/mdc3.13661 Text en © 2023 The Authors. Movement Disorders Clinical Practice published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Research Articles
Hughes, Shelby
Aboufadel, Sameer
Smirnova, Anna
Snell, Chase
Churchill, Emma
Hall, Andrew
Malcarne, Vanessa
Gilbert, Paul E.
Corey‐Bloom, Jody
Development and Psychometric Properties of a New Brief, Yet Comprehensive, Behavioral Questionnaire for Huntington's Disease
title Development and Psychometric Properties of a New Brief, Yet Comprehensive, Behavioral Questionnaire for Huntington's Disease
title_full Development and Psychometric Properties of a New Brief, Yet Comprehensive, Behavioral Questionnaire for Huntington's Disease
title_fullStr Development and Psychometric Properties of a New Brief, Yet Comprehensive, Behavioral Questionnaire for Huntington's Disease
title_full_unstemmed Development and Psychometric Properties of a New Brief, Yet Comprehensive, Behavioral Questionnaire for Huntington's Disease
title_short Development and Psychometric Properties of a New Brief, Yet Comprehensive, Behavioral Questionnaire for Huntington's Disease
title_sort development and psychometric properties of a new brief, yet comprehensive, behavioral questionnaire for huntington's disease
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10026282/
https://www.ncbi.nlm.nih.gov/pubmed/36949805
http://dx.doi.org/10.1002/mdc3.13661
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