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Blood pressure and dementia risk by physical frailty in the elderly: a nationwide cohort study
BACKGROUND: Midlife hypertension has been recognized as a modifiable risk factor for dementia, but association between blood pressure (BP) in late life and dementia has been inconclusive. In addition, few studies have investigated effects of BP control on dementia incidence in the frail elderly. Thu...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10026431/ https://www.ncbi.nlm.nih.gov/pubmed/36941727 http://dx.doi.org/10.1186/s13195-023-01211-y |
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author | Cho, Mi Hee Han, Kyungdo Lee, Seungwoo Jeong, Su-Min Yoo, Jung Eun Kim, SangYun Lee, Jinkook Chun, Sohyun Shin, Dong Wook |
author_facet | Cho, Mi Hee Han, Kyungdo Lee, Seungwoo Jeong, Su-Min Yoo, Jung Eun Kim, SangYun Lee, Jinkook Chun, Sohyun Shin, Dong Wook |
author_sort | Cho, Mi Hee |
collection | PubMed |
description | BACKGROUND: Midlife hypertension has been recognized as a modifiable risk factor for dementia, but association between blood pressure (BP) in late life and dementia has been inconclusive. In addition, few studies have investigated effects of BP control on dementia incidence in the frail elderly. Thus, this study aimed to investigate the association of BP and dementia incidence with concomitant consideration of physical frailty in the young elderly population. METHODS: Using the Korean National Health Information Database, we identified 804,024 subjects without history of dementia at age 66. Dementia diagnosis was defined with prescription records of anti-dementia drugs and dementia-related diagnostic codes. Physical frailty was measured using the Timed Up and Go test. Association of BP and dementia incidence with concomitant consideration of physical frailty was investigated using Cox hazards analyses. RESULTS: The risks of Alzheimer’s and vascular dementia increased from systolic BP ≥ 160 and 130–139 mmHg, respectively; a significant association of dementia incidence with low BP was not observed. In the analyses stratified by the physical frailty status, low BP was not associated with increased risks of dementia within the groups both with and without physical frailty. CONCLUSIONS: High BP was associated with increased risks of dementia, especially for vascular dementia, while low BP was not associated with increased risks of any type of dementia in young elderly people, even in those with physical frailty. This study suggests the need for tight BP control in young elderly people, irrespective of frailty status, to prevent dementia and supports the current clinical guidelines of hypertension treatment. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s13195-023-01211-y. |
format | Online Article Text |
id | pubmed-10026431 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-100264312023-03-21 Blood pressure and dementia risk by physical frailty in the elderly: a nationwide cohort study Cho, Mi Hee Han, Kyungdo Lee, Seungwoo Jeong, Su-Min Yoo, Jung Eun Kim, SangYun Lee, Jinkook Chun, Sohyun Shin, Dong Wook Alzheimers Res Ther Research BACKGROUND: Midlife hypertension has been recognized as a modifiable risk factor for dementia, but association between blood pressure (BP) in late life and dementia has been inconclusive. In addition, few studies have investigated effects of BP control on dementia incidence in the frail elderly. Thus, this study aimed to investigate the association of BP and dementia incidence with concomitant consideration of physical frailty in the young elderly population. METHODS: Using the Korean National Health Information Database, we identified 804,024 subjects without history of dementia at age 66. Dementia diagnosis was defined with prescription records of anti-dementia drugs and dementia-related diagnostic codes. Physical frailty was measured using the Timed Up and Go test. Association of BP and dementia incidence with concomitant consideration of physical frailty was investigated using Cox hazards analyses. RESULTS: The risks of Alzheimer’s and vascular dementia increased from systolic BP ≥ 160 and 130–139 mmHg, respectively; a significant association of dementia incidence with low BP was not observed. In the analyses stratified by the physical frailty status, low BP was not associated with increased risks of dementia within the groups both with and without physical frailty. CONCLUSIONS: High BP was associated with increased risks of dementia, especially for vascular dementia, while low BP was not associated with increased risks of any type of dementia in young elderly people, even in those with physical frailty. This study suggests the need for tight BP control in young elderly people, irrespective of frailty status, to prevent dementia and supports the current clinical guidelines of hypertension treatment. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s13195-023-01211-y. BioMed Central 2023-03-20 /pmc/articles/PMC10026431/ /pubmed/36941727 http://dx.doi.org/10.1186/s13195-023-01211-y Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Cho, Mi Hee Han, Kyungdo Lee, Seungwoo Jeong, Su-Min Yoo, Jung Eun Kim, SangYun Lee, Jinkook Chun, Sohyun Shin, Dong Wook Blood pressure and dementia risk by physical frailty in the elderly: a nationwide cohort study |
title | Blood pressure and dementia risk by physical frailty in the elderly: a nationwide cohort study |
title_full | Blood pressure and dementia risk by physical frailty in the elderly: a nationwide cohort study |
title_fullStr | Blood pressure and dementia risk by physical frailty in the elderly: a nationwide cohort study |
title_full_unstemmed | Blood pressure and dementia risk by physical frailty in the elderly: a nationwide cohort study |
title_short | Blood pressure and dementia risk by physical frailty in the elderly: a nationwide cohort study |
title_sort | blood pressure and dementia risk by physical frailty in the elderly: a nationwide cohort study |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10026431/ https://www.ncbi.nlm.nih.gov/pubmed/36941727 http://dx.doi.org/10.1186/s13195-023-01211-y |
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