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FGF-21 and GDF-15 are increased in migraine and associated with the severity of migraine-related disability
BACKGROUND: Migraine is a prevalent disorder with significant socioeconomic impact. The impairment of metabolic homeostasis in migraine warrants further investigation. Changes in serum levels of Fibroblast-growth-factor 21 (FGF-21) and Growth-differentiation-factor 15 (GDF-15) are characteristic of...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Milan
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10026504/ https://www.ncbi.nlm.nih.gov/pubmed/36935492 http://dx.doi.org/10.1186/s10194-023-01563-8 |
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author | He, Jiahui Zhou, Mengting Zhao, Fanglin Cheng, Hongrong Huang, Hao Xu, Xiaopei Han, Jian Hong, Wenwu Wang, Faming Xiao, Yujin Xia, Jinjin Liu, Kaiming |
author_facet | He, Jiahui Zhou, Mengting Zhao, Fanglin Cheng, Hongrong Huang, Hao Xu, Xiaopei Han, Jian Hong, Wenwu Wang, Faming Xiao, Yujin Xia, Jinjin Liu, Kaiming |
author_sort | He, Jiahui |
collection | PubMed |
description | BACKGROUND: Migraine is a prevalent disorder with significant socioeconomic impact. The impairment of metabolic homeostasis in migraine warrants further investigation. Changes in serum levels of Fibroblast-growth-factor 21 (FGF-21) and Growth-differentiation-factor 15 (GDF-15) are characteristic of some metabolic and mitochondrial diseases. This study aimed to assess whether the presence of migraine affects serum levels of FGF-21 and GDF-15, and taking metabolic disorders into account as potential confounding factors. METHODS: We collected serum samples from 221 migraine patients (153 episodic migraineurs and 68 chronic migraineurs) and 124 healthy controls. The serum concentrations of FGF-21 and GDF-15 were measured using an enzyme-linked immunosorbent assay (ELISA) based approach. Clinical variables, including monthly headache days, peak headache pain intensity, the 6-item Headache Impact Test (HIT-6), and the Migraine Disability Assessment (MIDAS), were also addressed. The associations between the clinical variables of migraine patients and serum levels of FGF-21 and GDF-15 were studied. RESULTS: In the multiple regression that corrected for age, we found that the serum levels of FGF-21 and GDF-15 were significantly higher in migraine sufferers than in healthy controls. A significant elevation in serum concentration of FGF-21, but not GDF-15, was observed in patients with chronic migraine (CM) compared to those with episodic migraine (EM). Regarding migraine-related disability, higher scores on the HIT-6 and MIDAS were associated with higher levels of FGF-21 and GDF-15. For the receiver operating characteristic (ROC) analysis, the diagnosis of migraine using GDF-15 showed that the area under the ROC curve (AUC) was 0.801 and the AUC of chronic migraine was 0.880. CONCLUSION: Serum GDF-15 and FGF-21 levels are increased in patients with migraine and associated with the severity of migraine-related disability. |
format | Online Article Text |
id | pubmed-10026504 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Springer Milan |
record_format | MEDLINE/PubMed |
spelling | pubmed-100265042023-03-21 FGF-21 and GDF-15 are increased in migraine and associated with the severity of migraine-related disability He, Jiahui Zhou, Mengting Zhao, Fanglin Cheng, Hongrong Huang, Hao Xu, Xiaopei Han, Jian Hong, Wenwu Wang, Faming Xiao, Yujin Xia, Jinjin Liu, Kaiming J Headache Pain Research BACKGROUND: Migraine is a prevalent disorder with significant socioeconomic impact. The impairment of metabolic homeostasis in migraine warrants further investigation. Changes in serum levels of Fibroblast-growth-factor 21 (FGF-21) and Growth-differentiation-factor 15 (GDF-15) are characteristic of some metabolic and mitochondrial diseases. This study aimed to assess whether the presence of migraine affects serum levels of FGF-21 and GDF-15, and taking metabolic disorders into account as potential confounding factors. METHODS: We collected serum samples from 221 migraine patients (153 episodic migraineurs and 68 chronic migraineurs) and 124 healthy controls. The serum concentrations of FGF-21 and GDF-15 were measured using an enzyme-linked immunosorbent assay (ELISA) based approach. Clinical variables, including monthly headache days, peak headache pain intensity, the 6-item Headache Impact Test (HIT-6), and the Migraine Disability Assessment (MIDAS), were also addressed. The associations between the clinical variables of migraine patients and serum levels of FGF-21 and GDF-15 were studied. RESULTS: In the multiple regression that corrected for age, we found that the serum levels of FGF-21 and GDF-15 were significantly higher in migraine sufferers than in healthy controls. A significant elevation in serum concentration of FGF-21, but not GDF-15, was observed in patients with chronic migraine (CM) compared to those with episodic migraine (EM). Regarding migraine-related disability, higher scores on the HIT-6 and MIDAS were associated with higher levels of FGF-21 and GDF-15. For the receiver operating characteristic (ROC) analysis, the diagnosis of migraine using GDF-15 showed that the area under the ROC curve (AUC) was 0.801 and the AUC of chronic migraine was 0.880. CONCLUSION: Serum GDF-15 and FGF-21 levels are increased in patients with migraine and associated with the severity of migraine-related disability. Springer Milan 2023-03-20 /pmc/articles/PMC10026504/ /pubmed/36935492 http://dx.doi.org/10.1186/s10194-023-01563-8 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research He, Jiahui Zhou, Mengting Zhao, Fanglin Cheng, Hongrong Huang, Hao Xu, Xiaopei Han, Jian Hong, Wenwu Wang, Faming Xiao, Yujin Xia, Jinjin Liu, Kaiming FGF-21 and GDF-15 are increased in migraine and associated with the severity of migraine-related disability |
title | FGF-21 and GDF-15 are increased in migraine and associated with the severity of migraine-related disability |
title_full | FGF-21 and GDF-15 are increased in migraine and associated with the severity of migraine-related disability |
title_fullStr | FGF-21 and GDF-15 are increased in migraine and associated with the severity of migraine-related disability |
title_full_unstemmed | FGF-21 and GDF-15 are increased in migraine and associated with the severity of migraine-related disability |
title_short | FGF-21 and GDF-15 are increased in migraine and associated with the severity of migraine-related disability |
title_sort | fgf-21 and gdf-15 are increased in migraine and associated with the severity of migraine-related disability |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10026504/ https://www.ncbi.nlm.nih.gov/pubmed/36935492 http://dx.doi.org/10.1186/s10194-023-01563-8 |
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