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Clinical significance of the histopathological metastatic largest lymph node size in colorectal cancer patients
BACKGROUND: The metastatic lymph nodes (MLN) are interpreted to be correlated with prognosis of the colorectal cancers (CRC). The present retrospective study aimed to investigate the clinical significance of the largest MLN size in terms of postoperative outcomes and its predictive value in the prog...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10027072/ https://www.ncbi.nlm.nih.gov/pubmed/36950545 http://dx.doi.org/10.3389/fonc.2023.1120753 |
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author | Omeroglu, Sinan Gulmez, Selcuk Uzun, Orhan Senger, Aziz Serkan Bostanci, Ozgur Guven, Onur Polat, Erdal Duman, Mustafa |
author_facet | Omeroglu, Sinan Gulmez, Selcuk Uzun, Orhan Senger, Aziz Serkan Bostanci, Ozgur Guven, Onur Polat, Erdal Duman, Mustafa |
author_sort | Omeroglu, Sinan |
collection | PubMed |
description | BACKGROUND: The metastatic lymph nodes (MLN) are interpreted to be correlated with prognosis of the colorectal cancers (CRC). The present retrospective study aimed to investigate the clinical significance of the largest MLN size in terms of postoperative outcomes and its predictive value in the prognosis of the patients with stage III CRC. METHODS: Between May 2013 and December 2018, a total of 101 patients who underwent curative resection for stage III CRC retrospectively reviewed. All patients were divided into two groups regarding cut-off value (<1.05 cm and ≥1.05 cm) of maximum MLN diameter measured histopathologically. A comparative analysis of demographic and clinicopathological characteristics of the patients and their postoperative outcomes were performed. RESULTS: Two groups carried similar demographic data and preoperative laboratory variables except the lymphocyte count, hematocrit (HCT) ratio, hemoglobin level and mean corpuscular volume (MCV) value (p<0.05). The patients with MLN diameter ≥1.05 cm (n=46) needed more erythrocyte suspension and were hospitalized longer than the patients with a diameter <1.05 cm (n=55) (p=0.006 and 0.0294, respectively). Patients with MLN diameter < 1.05 cm had a significantly longer overall survival than patients with MLN diameter ≥ 1.05 cm (75,29 vs. 52,57 months, respectively). Regarding the histopathologic features, the patients with MLN diameter ≥1.05 cm had larger tumor size and higher number of MLN than those with diameter <1.05 cm (p=0.049 and 0.001). CONCLUSION: The size of MLN larger than 1.05 cm may be predictive for a poor prognosis and lower survival of stage III CRC patients. The largest MLN size may be a proper alternative factor to the number of MLNs in predicting prognosis or in staging CRC patients. |
format | Online Article Text |
id | pubmed-10027072 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-100270722023-03-21 Clinical significance of the histopathological metastatic largest lymph node size in colorectal cancer patients Omeroglu, Sinan Gulmez, Selcuk Uzun, Orhan Senger, Aziz Serkan Bostanci, Ozgur Guven, Onur Polat, Erdal Duman, Mustafa Front Oncol Oncology BACKGROUND: The metastatic lymph nodes (MLN) are interpreted to be correlated with prognosis of the colorectal cancers (CRC). The present retrospective study aimed to investigate the clinical significance of the largest MLN size in terms of postoperative outcomes and its predictive value in the prognosis of the patients with stage III CRC. METHODS: Between May 2013 and December 2018, a total of 101 patients who underwent curative resection for stage III CRC retrospectively reviewed. All patients were divided into two groups regarding cut-off value (<1.05 cm and ≥1.05 cm) of maximum MLN diameter measured histopathologically. A comparative analysis of demographic and clinicopathological characteristics of the patients and their postoperative outcomes were performed. RESULTS: Two groups carried similar demographic data and preoperative laboratory variables except the lymphocyte count, hematocrit (HCT) ratio, hemoglobin level and mean corpuscular volume (MCV) value (p<0.05). The patients with MLN diameter ≥1.05 cm (n=46) needed more erythrocyte suspension and were hospitalized longer than the patients with a diameter <1.05 cm (n=55) (p=0.006 and 0.0294, respectively). Patients with MLN diameter < 1.05 cm had a significantly longer overall survival than patients with MLN diameter ≥ 1.05 cm (75,29 vs. 52,57 months, respectively). Regarding the histopathologic features, the patients with MLN diameter ≥1.05 cm had larger tumor size and higher number of MLN than those with diameter <1.05 cm (p=0.049 and 0.001). CONCLUSION: The size of MLN larger than 1.05 cm may be predictive for a poor prognosis and lower survival of stage III CRC patients. The largest MLN size may be a proper alternative factor to the number of MLNs in predicting prognosis or in staging CRC patients. Frontiers Media S.A. 2023-03-06 /pmc/articles/PMC10027072/ /pubmed/36950545 http://dx.doi.org/10.3389/fonc.2023.1120753 Text en Copyright © 2023 Omeroglu, Gulmez, Uzun, Senger, Bostanci, Guven, Polat and Duman https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Oncology Omeroglu, Sinan Gulmez, Selcuk Uzun, Orhan Senger, Aziz Serkan Bostanci, Ozgur Guven, Onur Polat, Erdal Duman, Mustafa Clinical significance of the histopathological metastatic largest lymph node size in colorectal cancer patients |
title | Clinical significance of the histopathological metastatic largest lymph node size in colorectal cancer patients |
title_full | Clinical significance of the histopathological metastatic largest lymph node size in colorectal cancer patients |
title_fullStr | Clinical significance of the histopathological metastatic largest lymph node size in colorectal cancer patients |
title_full_unstemmed | Clinical significance of the histopathological metastatic largest lymph node size in colorectal cancer patients |
title_short | Clinical significance of the histopathological metastatic largest lymph node size in colorectal cancer patients |
title_sort | clinical significance of the histopathological metastatic largest lymph node size in colorectal cancer patients |
topic | Oncology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10027072/ https://www.ncbi.nlm.nih.gov/pubmed/36950545 http://dx.doi.org/10.3389/fonc.2023.1120753 |
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