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Causes of death identified in neonates enrolled through Child Health and Mortality Prevention Surveillance (CHAMPS), December 2016 –December 2021

Each year, 2.4 million children die within their first month of life. Child Health and Mortality Prevention Surveillance (CHAMPS) established in 7 countries aims to generate accurate data on why such deaths occur and inform prevention strategies. Neonatal deaths that occurred between December 2016 a...

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Autores principales: Mahtab, Sana, Madhi, Shabir A., Baillie, Vicky L., Els, Toyah, Thwala, Bukiwe Nana, Onyango, Dickens, Tippet-Barr, Beth A., Akelo, Victor, Igunza, Kitiezo Aggrey, Omore, Richard, Arifeen, Shams El, Gurley, Emily S., Alam, Muntasir, Chowdhury, Atique Iqbal, Rahman, Afruna, Bassat, Quique, Mandomando, Inacio, Ajanovic, Sara, Sitoe, Antonio, Varo, Rosauro, Sow, Samba O., Kotloff, Karen L., Badji, Henry, Tapia, Milagritos D., Traore, Cheick B., Ogbuanu, Ikechukwu U., Bunn, James, Luke, Ronita, Sannoh, Sulaiman, Swarray-Deen, Alim, Assefa, Nega, Scott, J. Anthony G., Madrid, Lola, Marami, Dadi, Fentaw, Surafel, Diaz, Maureen H., Martines, Roosecelis B., Breiman, Robert F., Madewell, Zachary J., Blau, Dianna M., Whitney, Cynthia G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10027211/
https://www.ncbi.nlm.nih.gov/pubmed/36963040
http://dx.doi.org/10.1371/journal.pgph.0001612
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author Mahtab, Sana
Madhi, Shabir A.
Baillie, Vicky L.
Els, Toyah
Thwala, Bukiwe Nana
Onyango, Dickens
Tippet-Barr, Beth A.
Akelo, Victor
Igunza, Kitiezo Aggrey
Omore, Richard
Arifeen, Shams El
Gurley, Emily S.
Alam, Muntasir
Chowdhury, Atique Iqbal
Rahman, Afruna
Bassat, Quique
Mandomando, Inacio
Ajanovic, Sara
Sitoe, Antonio
Varo, Rosauro
Sow, Samba O.
Kotloff, Karen L.
Badji, Henry
Tapia, Milagritos D.
Traore, Cheick B.
Ogbuanu, Ikechukwu U.
Bunn, James
Luke, Ronita
Sannoh, Sulaiman
Swarray-Deen, Alim
Assefa, Nega
Scott, J. Anthony G.
Madrid, Lola
Marami, Dadi
Fentaw, Surafel
Diaz, Maureen H.
Martines, Roosecelis B.
Breiman, Robert F.
Madewell, Zachary J.
Blau, Dianna M.
Whitney, Cynthia G.
author_facet Mahtab, Sana
Madhi, Shabir A.
Baillie, Vicky L.
Els, Toyah
Thwala, Bukiwe Nana
Onyango, Dickens
Tippet-Barr, Beth A.
Akelo, Victor
Igunza, Kitiezo Aggrey
Omore, Richard
Arifeen, Shams El
Gurley, Emily S.
Alam, Muntasir
Chowdhury, Atique Iqbal
Rahman, Afruna
Bassat, Quique
Mandomando, Inacio
Ajanovic, Sara
Sitoe, Antonio
Varo, Rosauro
Sow, Samba O.
Kotloff, Karen L.
Badji, Henry
Tapia, Milagritos D.
Traore, Cheick B.
Ogbuanu, Ikechukwu U.
Bunn, James
Luke, Ronita
Sannoh, Sulaiman
Swarray-Deen, Alim
Assefa, Nega
Scott, J. Anthony G.
Madrid, Lola
Marami, Dadi
Fentaw, Surafel
Diaz, Maureen H.
Martines, Roosecelis B.
Breiman, Robert F.
Madewell, Zachary J.
Blau, Dianna M.
Whitney, Cynthia G.
author_sort Mahtab, Sana
collection PubMed
description Each year, 2.4 million children die within their first month of life. Child Health and Mortality Prevention Surveillance (CHAMPS) established in 7 countries aims to generate accurate data on why such deaths occur and inform prevention strategies. Neonatal deaths that occurred between December 2016 and December 2021 were investigated with MITS within 24–72 hours of death. Testing included blood, cerebrospinal fluid and lung cultures, multi-pathogen PCR on blood, CSF, nasopharyngeal swabs and lung tissue, and histopathology examination of lung, liver and brain. Data collection included clinical record review and family interview using standardized verbal autopsy. The full set of data was reviewed by local experts using a standardized process (Determination of Cause of Death) to identify all relevant conditions leading to death (causal chain), per WHO recommendations. For analysis we stratified neonatal death into 24-hours of birth, early (1-<7 days) and late (7-<28 days) neonatal deaths. We analyzed 1458 deaths, 41% occurring within 24-hours, 41% early and 18% late neonatal deaths. Leading underlying causes of death were complications of intrapartum events (31%), complications of prematurity (28%), infections (17%), respiratory disorders (11%), and congenital malformations (8%). In addition to the underlying cause, 62% of deaths had additional conditions and 14% had ≥3 other conditions in the causal chain. The most common causes considering the whole causal chain were infection (40%), prematurity (32%) and respiratory distress syndrome (28%). Common maternal conditions linked to neonatal death were maternal hypertension (10%), labour and delivery complications (8%), multiple gestation (7%), placental complications (6%) obstructed labour and chorioamnionitis (5%, each). CHAMPS’ findings showing the full causal chain of events that lead to death, in addition to maternal factors, highlights the complexities involved in each death along with the multiple opportunities for prevention. Highlighting improvements to prenatal and obstetric care and infection prevention are urgently needed in high-mortality settings.
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spelling pubmed-100272112023-03-21 Causes of death identified in neonates enrolled through Child Health and Mortality Prevention Surveillance (CHAMPS), December 2016 –December 2021 Mahtab, Sana Madhi, Shabir A. Baillie, Vicky L. Els, Toyah Thwala, Bukiwe Nana Onyango, Dickens Tippet-Barr, Beth A. Akelo, Victor Igunza, Kitiezo Aggrey Omore, Richard Arifeen, Shams El Gurley, Emily S. Alam, Muntasir Chowdhury, Atique Iqbal Rahman, Afruna Bassat, Quique Mandomando, Inacio Ajanovic, Sara Sitoe, Antonio Varo, Rosauro Sow, Samba O. Kotloff, Karen L. Badji, Henry Tapia, Milagritos D. Traore, Cheick B. Ogbuanu, Ikechukwu U. Bunn, James Luke, Ronita Sannoh, Sulaiman Swarray-Deen, Alim Assefa, Nega Scott, J. Anthony G. Madrid, Lola Marami, Dadi Fentaw, Surafel Diaz, Maureen H. Martines, Roosecelis B. Breiman, Robert F. Madewell, Zachary J. Blau, Dianna M. Whitney, Cynthia G. PLOS Glob Public Health Research Article Each year, 2.4 million children die within their first month of life. Child Health and Mortality Prevention Surveillance (CHAMPS) established in 7 countries aims to generate accurate data on why such deaths occur and inform prevention strategies. Neonatal deaths that occurred between December 2016 and December 2021 were investigated with MITS within 24–72 hours of death. Testing included blood, cerebrospinal fluid and lung cultures, multi-pathogen PCR on blood, CSF, nasopharyngeal swabs and lung tissue, and histopathology examination of lung, liver and brain. Data collection included clinical record review and family interview using standardized verbal autopsy. The full set of data was reviewed by local experts using a standardized process (Determination of Cause of Death) to identify all relevant conditions leading to death (causal chain), per WHO recommendations. For analysis we stratified neonatal death into 24-hours of birth, early (1-<7 days) and late (7-<28 days) neonatal deaths. We analyzed 1458 deaths, 41% occurring within 24-hours, 41% early and 18% late neonatal deaths. Leading underlying causes of death were complications of intrapartum events (31%), complications of prematurity (28%), infections (17%), respiratory disorders (11%), and congenital malformations (8%). In addition to the underlying cause, 62% of deaths had additional conditions and 14% had ≥3 other conditions in the causal chain. The most common causes considering the whole causal chain were infection (40%), prematurity (32%) and respiratory distress syndrome (28%). Common maternal conditions linked to neonatal death were maternal hypertension (10%), labour and delivery complications (8%), multiple gestation (7%), placental complications (6%) obstructed labour and chorioamnionitis (5%, each). CHAMPS’ findings showing the full causal chain of events that lead to death, in addition to maternal factors, highlights the complexities involved in each death along with the multiple opportunities for prevention. Highlighting improvements to prenatal and obstetric care and infection prevention are urgently needed in high-mortality settings. Public Library of Science 2023-03-20 /pmc/articles/PMC10027211/ /pubmed/36963040 http://dx.doi.org/10.1371/journal.pgph.0001612 Text en © 2023 Mahtab et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Mahtab, Sana
Madhi, Shabir A.
Baillie, Vicky L.
Els, Toyah
Thwala, Bukiwe Nana
Onyango, Dickens
Tippet-Barr, Beth A.
Akelo, Victor
Igunza, Kitiezo Aggrey
Omore, Richard
Arifeen, Shams El
Gurley, Emily S.
Alam, Muntasir
Chowdhury, Atique Iqbal
Rahman, Afruna
Bassat, Quique
Mandomando, Inacio
Ajanovic, Sara
Sitoe, Antonio
Varo, Rosauro
Sow, Samba O.
Kotloff, Karen L.
Badji, Henry
Tapia, Milagritos D.
Traore, Cheick B.
Ogbuanu, Ikechukwu U.
Bunn, James
Luke, Ronita
Sannoh, Sulaiman
Swarray-Deen, Alim
Assefa, Nega
Scott, J. Anthony G.
Madrid, Lola
Marami, Dadi
Fentaw, Surafel
Diaz, Maureen H.
Martines, Roosecelis B.
Breiman, Robert F.
Madewell, Zachary J.
Blau, Dianna M.
Whitney, Cynthia G.
Causes of death identified in neonates enrolled through Child Health and Mortality Prevention Surveillance (CHAMPS), December 2016 –December 2021
title Causes of death identified in neonates enrolled through Child Health and Mortality Prevention Surveillance (CHAMPS), December 2016 –December 2021
title_full Causes of death identified in neonates enrolled through Child Health and Mortality Prevention Surveillance (CHAMPS), December 2016 –December 2021
title_fullStr Causes of death identified in neonates enrolled through Child Health and Mortality Prevention Surveillance (CHAMPS), December 2016 –December 2021
title_full_unstemmed Causes of death identified in neonates enrolled through Child Health and Mortality Prevention Surveillance (CHAMPS), December 2016 –December 2021
title_short Causes of death identified in neonates enrolled through Child Health and Mortality Prevention Surveillance (CHAMPS), December 2016 –December 2021
title_sort causes of death identified in neonates enrolled through child health and mortality prevention surveillance (champs), december 2016 –december 2021
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10027211/
https://www.ncbi.nlm.nih.gov/pubmed/36963040
http://dx.doi.org/10.1371/journal.pgph.0001612
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